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Simulating realistic patient profiles from pharmacokinetic models by a machine learning postprocessing correction of residual variability.
CPT Pharmacometrics Syst Pharmacol. 2024 Sep;13(9):1476-1487. doi: 10.1002/psp4.13182. Epub 2024 Jun 14.
CPT Pharmacometrics Syst Pharmacol. 2024.
PMID: 38877660
Free PMC article.
Donepezil Brain and Blood Pharmacokinetic Modeling after Nasal Film and Oral Solution Administration in Mice.
Kaikousidis C, Papakyriakopoulou P, Dokoumetzidis A, Valsami G.
Kaikousidis C, et al.
Pharmaceutics. 2023 May 5;15(5):1409. doi: 10.3390/pharmaceutics15051409.
Pharmaceutics. 2023.
PMID: 37242651
Free PMC article.
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Implementation of non-linear mixed effects models defined by fractional differential equations.
Kaikousidis C, Dokoumetzidis A.
Kaikousidis C, et al.
J Pharmacokinet Pharmacodyn. 2023 Aug;50(4):283-295. doi: 10.1007/s10928-023-09851-1. Epub 2023 Mar 21.
J Pharmacokinet Pharmacodyn. 2023.
PMID: 36944853
Free PMC article.
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In Silico Dosimetry Study of Tc99m-Tetrofosmin in Children Using a Novel PBPK Model in Humans Built from SPECT Imaging Data.
Kaikousidis C, Dokoumetzidis A.
Kaikousidis C, et al.
Pharm Res. 2023 Feb;40(2):449-458. doi: 10.1007/s11095-022-03412-w. Epub 2022 Oct 19.
Pharm Res. 2023.
PMID: 36261760
Free PMC article.
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