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Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes.
Kizilkaya HS, Sørensen KV, Madsen JS, Lindquist P, Douros JD, Bork-Jensen J, Berghella A, Gerlach PA, Gasbjerg LS, Mokrosiński J, Mowery SA, Knerr PJ, Finan B, Campbell JE, D'Alessio DA, Perez-Tilve D, Faas F, Mathiasen S, Rungby J, Sørensen HT, Vaag A, Nielsen JS, Holm JC, Lauenborg J, Damm P, Pedersen O, Linneberg A, Hartmann B, Holst JJ, Hansen T, Wright SC, Lauschke VM, Grarup N, Hauser AS, Rosenkilde MM. Kizilkaya HS, et al. Among authors: rosenkilde mm. Nat Metab. 2024 Jul;6(7):1268-1281. doi: 10.1038/s42255-024-01061-4. Epub 2024 Jun 13. Nat Metab. 2024. PMID: 38871982 Free PMC article.
2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.
Hansen KB, Rosenkilde MM, Knop FK, Wellner N, Diep TA, Rehfeld JF, Andersen UB, Holst JJ, Hansen HS. Hansen KB, et al. Among authors: rosenkilde mm. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17. doi: 10.1210/jc.2011-0647. Epub 2011 Jul 21. J Clin Endocrinol Metab. 2011. PMID: 21778222
Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1.
Torekov SS, Ma L, Grarup N, Hartmann B, Hainerová IA, Kielgast U, Kissow H, Rosenkilde M; GIANT Consortium; Lebl J, Witte DR, Jørgensen T, Sandbaek A, Lauritzen T, Madsen OD, Wang J, Linneberg A, Madsbad S, Holst JJ, Hansen T, Pedersen O. Torekov SS, et al. Diabetologia. 2011 Nov;54(11):2820-31. doi: 10.1007/s00125-011-2265-7. Epub 2011 Aug 7. Diabetologia. 2011. PMID: 21822931
Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain.
Ugleholdt R, Pedersen J, Bassi MR, Füchtbauer EM, Jørgensen SM, Kissow HL, Nytofte N, Poulsen SS, Rosenkilde MM, Seino Y, Thams P, Holst PJ, Holst JJ. Ugleholdt R, et al. Among authors: rosenkilde mm. J Biol Chem. 2011 Dec 30;286(52):44632-45. doi: 10.1074/jbc.M111.311779. Epub 2011 Oct 25. J Biol Chem. 2011. PMID: 22027838 Free PMC article.
280 results