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Page 1
Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge.
Gasbjerg LS, Rasmussen RS, Dragan A, Lindquist P, Melchiorsen JU, Stepniewski TM, Schiellerup S, Tordrup EK, Gadgaard S, Kizilkaya HS, Willems S, Zhong Y, Wang Y, Wright SC, Lauschke VM, Hartmann B, Holst JJ, Selent J, Rosenkilde MM. Gasbjerg LS, et al. Among authors: kizilkaya hs. Br J Pharmacol. 2024 Jul 1. doi: 10.1111/bph.16478. Online ahead of print. Br J Pharmacol. 2024. PMID: 38952084
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes.
Kizilkaya HS, Sørensen KV, Madsen JS, Lindquist P, Douros JD, Bork-Jensen J, Berghella A, Gerlach PA, Gasbjerg LS, Mokrosiński J, Mowery SA, Knerr PJ, Finan B, Campbell JE, D'Alessio DA, Perez-Tilve D, Faas F, Mathiasen S, Rungby J, Sørensen HT, Vaag A, Nielsen JS, Holm JC, Lauenborg J, Damm P, Pedersen O, Linneberg A, Hartmann B, Holst JJ, Hansen T, Wright SC, Lauschke VM, Grarup N, Hauser AS, Rosenkilde MM. Kizilkaya HS, et al. Nat Metab. 2024 Jul;6(7):1268-1281. doi: 10.1038/s42255-024-01061-4. Epub 2024 Jun 13. Nat Metab. 2024. PMID: 38871982 Free PMC article.
Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes.
Melchiorsen JU, Sørensen KV, Bork-Jensen J, Kizilkaya HS, Gasbjerg LS, Hauser AS, Rungby J, Sørensen HT, Vaag A, Nielsen JS, Pedersen O, Linneberg A, Hartmann B, Gjesing AP, Holst JJ, Hansen T, Rosenkilde MM, Grarup N. Melchiorsen JU, et al. Among authors: kizilkaya hs. J Clin Endocrinol Metab. 2023 Oct 18;108(11):2821-2833. doi: 10.1210/clinem/dgad290. J Clin Endocrinol Metab. 2023. PMID: 37235780 Free PMC article.
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
Galsgaard KD, Elmelund E, Johansen CD, Bomholt AB, Kizilkaya HS, Ceutz F, Hunt JE, Kissow H, Winther-Sørensen M, Sørensen CM, Kruse T, Lau JF, Rosenkilde MM, Ørskov C, Christoffersen C, Holst JJ, Wewer Albrechtsen NJ. Galsgaard KD, et al. Among authors: kizilkaya hs. Mol Metab. 2022 Dec;66:101639. doi: 10.1016/j.molmet.2022.101639. Epub 2022 Nov 15. Mol Metab. 2022. PMID: 36400402 Free PMC article.
L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion.
Kuhre RE, Modvig IM, Jepsen SL, Kizilkaya HS, Bæch-Laursen C, Smith CA, Reimann F, Gribble FM, Rosenkilde MM, Holst JJ. Kuhre RE, et al. Among authors: kizilkaya hs. Front Endocrinol (Lausanne). 2021 Aug 5;12:690387. doi: 10.3389/fendo.2021.690387. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34421821 Free PMC article.
Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor.
Smit FX, van der Velden WJC, Kizilkaya HS, Nørskov A, Lückmann M, Hansen TN, Sparre-Ulrich AH, Qvotrup K, Frimurer TM, Rosenkilde MM. Smit FX, et al. Among authors: kizilkaya hs. Structure. 2021 Jul 1;29(7):679-693.e6. doi: 10.1016/j.str.2021.04.001. Epub 2021 Apr 22. Structure. 2021. PMID: 33891864 Free article.
11 results