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Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn's Disease.
Dennison TW, Edgar RD, Payne F, Nayak KM, Ross ADB, Cenier A, Glemas C, Giachero F, Foster AR, Harris R, Kraiczy J, Salvestrini C, Stavrou G, Torrente F, Brook K, Trayers C, Elmentaite R, Youssef G, Tél B, Winton DJ, Skoufou-Papoutsaki N, Adler S, Bufler P, Azabdaftari A, Jenke A, G N, Thomas N, Miele E, Al-Mohammad A, Guarda G, Kugathasan S, Venkateswaran S, Clatworthy MR, Castro-Dopico T, Suchanek O, Strisciuglio C, Gasparetto M, Lee S, Xu X, Bello E, Han N, Zerbino DR, Teichmann SA, Nys J, Heuschkel R, Perrone F, Zilbauer M. Dennison TW, et al. Among authors: clatworthy mr. Gut. 2024 Aug 8;73(9):1464-1477. doi: 10.1136/gutjnl-2024-332043. Gut. 2024. PMID: 38857990 Free PMC article.
Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis.
Pacyna CN, Anandapadamanaban M, Loudon KW, Hay IM, Perisic O, Li R, Byrne M, Allen L, Roberts K, Hooks Y, Warren AY, Stewart GD, Clatworthy MR, Teichmann SA, Behjati S, Campbell PJ, Williams RL, Mitchell TJ. Pacyna CN, et al. Among authors: clatworthy mr. Oncogene. 2024 Oct;43(44):3268-3276. doi: 10.1038/s41388-024-03137-7. Epub 2024 Sep 13. Oncogene. 2024. PMID: 39271965 Free PMC article.
Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury.
Subramanian A, Vernon KA, Zhou Y, Marshall JL, Alimova M, Arevalo C, Zhang F, Slyper M, Waldman J, Montesinos MS, Dionne D, Nguyen LT, Cuoco MS, Dubinsky D, Purnell J, Keller K, Sturner SH, Grinkevich E, Ghoshal A, Kotek A, Trivioli G, Richoz N, Humphrey MB, Darby IG, Miller SJ, Xu Y, Weins A, Chloe-Villani A, Chang SL, Kretzler M, Rosenblatt-Rosen O, Shaw JL, Zimmerman KA, Clatworthy MR, Regev A, Greka A. Subramanian A, et al. Among authors: clatworthy mr. Cell Rep. 2024 Jun 25;43(6):114253. doi: 10.1016/j.celrep.2024.114253. Epub 2024 May 22. Cell Rep. 2024. PMID: 38781074 Free PMC article.
A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells.
Ulezko Antonova A, Lonardi S, Monti M, Missale F, Fan C, Coates ML, Bugatti M, Jaeger N, Fernandes Rodrigues P, Brioschi S, Trsan T, Fachi JL, Nguyen KM, Nunley RM, Moratto D, Zini S, Kong L, Deguine J, Peeples ME, Xavier RJ, Clatworthy MR, Wang T, Cella M, Vermi W, Colonna M. Ulezko Antonova A, et al. Among authors: clatworthy mr. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2318710120. doi: 10.1073/pnas.2318710120. Epub 2023 Dec 18. Proc Natl Acad Sci U S A. 2023. PMID: 38109523 Free PMC article.
Regulatory T-Cell Response to Low-Dose Interleukin-2 in Ischemic Heart Disease.
Zhao TX, Sriranjan RS, Tuong ZK, Lu Y, Sage AP, Nus M, Hubsch A, Kaloyirou F, Vamvaka E, Helmy J, Kostapanos M, Jalaludeen N, Klatzmann D, Tedgui A, Rudd JHF, Horton SJ, Huntly BJP, Hoole SP, Bond SP, Clatworthy MR, Cheriyan J, Mallat Z. Zhao TX, et al. Among authors: clatworthy mr. NEJM Evid. 2022 Jan;1(1):EVIDoa2100009. doi: 10.1056/EVIDoa2100009. Epub 2021 Nov 22. NEJM Evid. 2022. PMID: 38319239 Clinical Trial.
Study protocol for a randomised, phase II, double-blind, experimental medicine study of obinutuzumab versus rituximab in ANCA-associated vasculitis: ObiVas.
McGovern DP, McClure ME, Coates M, Bond S, Martinez Del Pero M, Mynard K, Lee J, Smith RM, Jayne DR, Clatworthy MR, Jones RB; ObiVas Investigators. McGovern DP, et al. Among authors: clatworthy mr. BMJ Open. 2024 Jul 17;14(7):e083277. doi: 10.1136/bmjopen-2023-083277. BMJ Open. 2024. PMID: 39019638 Free PMC article. Clinical Trial.
The IBEX Knowledge-Base: Achieving more together with open science.
Radtke AJ, Anidi I, Arakkal L, Arroyo-Mejias A, Beuschel RT, Börner K, Chu CJ, Clark B, Clatworthy MR, Colautti J, Croteau J, Denha S, Dever R, Dutra WO, Fritzsche S, Fullam S, Gerner MY, Gola A, Gollob KJ, Hernandez JM, Hor JL, Ichise H, Jing Z, Jonigk D, Kandov E, Kastenmüller W, Koenig JFE, Kothurkar A, Kreins AY, Lamborn I, Lin Y, Luciano Pereira Morais K, Lunich A, Luz JCS, MacDonald RB, Makranz C, Maltez VI, Moriaty RV, Ocampo-Godinez JM, Olyntho VM, Padhan K, Remmert K, Richoz N, Schrom EC, Shang W, Shi L, Shih RM, Speranza E, Stierli S, Teichmann SA, Veres TZ, Vierhout M, Wachter BT, Wade-Vallance AK, Williams M, Zangger N, Germain RN, Yaniv Z. Radtke AJ, et al. Among authors: clatworthy mr. ArXiv [Preprint]. 2024 Jul 26:arXiv:2407.19059v1. ArXiv. 2024. PMID: 39398203 Free PMC article. Preprint.
160 results