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A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.
Ortega-Molina A, Lebrero-Fernández C, Sanz A, Calvo-Rubio M, Deleyto-Seldas N, de Prado-Rivas L, Plata-Gómez AB, Fernández-Florido E, González-García P, Vivas-García Y, Sánchez García E, Graña-Castro O, Price NL, Aroca-Crevillén A, Caleiras E, Monleón D, Borrás C, Casanova-Acebes M, de Cabo R, Efeyan A. Ortega-Molina A, et al. Among authors: efeyan a. Nat Aging. 2024 Aug;4(8):1102-1120. doi: 10.1038/s43587-024-00635-x. Epub 2024 Jun 7. Nat Aging. 2024. PMID: 38849535 Free PMC article.
Hepatic nutrient and hormone signaling to mTORC1 instructs the postnatal metabolic zonation of the liver.
Plata-Gómez AB, de Prado-Rivas L, Sanz A, Deleyto-Seldas N, García F, de la Calle Arregui C, Silva C, Caleiras E, Graña-Castro O, Piñeiro-Yáñez E, Krebs J, Leiva-Vega L, Muñoz J, Jain A, Sabio G, Efeyan A. Plata-Gómez AB, et al. Among authors: efeyan a. Nat Commun. 2024 Mar 18;15(1):1878. doi: 10.1038/s41467-024-46032-1. Nat Commun. 2024. PMID: 38499523 Free PMC article.
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.
de la Calle Arregui C, Plata-Gómez AB, Deleyto-Seldas N, García F, Ortega-Molina A, Abril-Garrido J, Rodriguez E, Nemazanyy I, Tribouillard L, de Martino A, Caleiras E, Campos-Olivas R, Mulero F, Laplante M, Muñoz J, Pende M, Sabio G, Sabatini DM, Efeyan A. de la Calle Arregui C, et al. Among authors: efeyan a. Nat Commun. 2021 Jun 16;12(1):3660. doi: 10.1038/s41467-021-23857-8. Nat Commun. 2021. PMID: 34135321 Free PMC article.
The mTOR-Autophagy Axis and the Control of Metabolism.
Deleyto-Seldas N, Efeyan A. Deleyto-Seldas N, et al. Among authors: efeyan a. Front Cell Dev Biol. 2021 Jul 1;9:655731. doi: 10.3389/fcell.2021.655731. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34277603 Free PMC article. Review.
From mouse genetics to targeting the Rag GTPase pathway.
Ortega-Molina A, Efeyan A. Ortega-Molina A, et al. Among authors: efeyan a. Mol Cell Oncol. 2021 Sep 24;8(5):1979370. doi: 10.1080/23723556.2021.1979370. eCollection 2021. Mol Cell Oncol. 2021. PMID: 34859142 Free PMC article.
AMPK knocks at the gate of GATOR.
Deleyto-Seldas N, Efeyan A. Deleyto-Seldas N, et al. Among authors: efeyan a. Nat Metab. 2023 Feb;5(2):197-198. doi: 10.1038/s42255-022-00729-z. Nat Metab. 2023. PMID: 36732623 No abstract available.
Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.
Ortega-Molina A, Deleyto-Seldas N, Carreras J, Sanz A, Lebrero-Fernández C, Menéndez C, Vandenberg A, Fernández-Ruiz B, Marín-Arraiza L, de la Calle Arregui C, Belén Plata-Gómez A, Caleiras E, de Martino A, Martínez-Martín N, Troulé K, Piñeiro-Yáñez E, Nakamura N, Araf S, Victora GD, Okosun J, Fitzgibbon J, Efeyan A. Ortega-Molina A, et al. Among authors: efeyan a. Nat Metab. 2019 Aug;1(8):775-789. doi: 10.1038/s42255-019-0098-8. Epub 2019 Aug 19. Nat Metab. 2019. PMID: 31579886 Free PMC article.
Protocol for the assessment of mTOR activity in mouse primary hepatocytes.
Plata-Gómez AB, Crespo M, de la Calle Arregui C, de Prado-Rivas L, Sabio G, Efeyan A. Plata-Gómez AB, et al. Among authors: efeyan a. STAR Protoc. 2021 Oct 29;2(4):100918. doi: 10.1016/j.xpro.2021.100918. eCollection 2021 Dec 17. STAR Protoc. 2021. PMID: 34755120 Free PMC article.
The metabolic plasticity of B cells.
Vivas-García Y, Efeyan A. Vivas-García Y, et al. Among authors: efeyan a. Front Mol Biosci. 2022 Sep 23;9:991188. doi: 10.3389/fmolb.2022.991188. eCollection 2022. Front Mol Biosci. 2022. PMID: 36213123 Free PMC article. Review.
57 results