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Page 1
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.
Xia Z, Prescott EE, Urbanek A, Wareing HE, King MC, Olerinyova A, Dakin H, Leah T, Barnes KA, Matuszyk MM, Dimou E, Hidari E, Zhang YP, Lam JYL, Danial JSH, Strickland MR, Jiang H, Thornton P, Crowther DC, Ohtonen S, Gómez-Budia M, Bell SM, Ferraiuolo L, Mortiboys H, Higginbottom A, Wharton SB, Holtzman DM, Malm T, Ranasinghe RT, Klenerman D, De S. Xia Z, et al. Among authors: ohtonen s. Nat Commun. 2024 Jun 1;15(1):4695. doi: 10.1038/s41467-024-49028-z. Nat Commun. 2024. PMID: 38824138 Free PMC article.
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.
Konttinen H, Cabral-da-Silva MEC, Ohtonen S, Wojciechowski S, Shakirzyanova A, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen MF, Eamen S, Budia MG, Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, Hewitt AW, Vickers J, Smith GC, Oksanen M, Graff C, Kanninen KM, Lehtonen S, Propson N, Schwartz MP, Pébay A, Koistinaho J, Ooi L, Malm T. Konttinen H, et al. Among authors: ohtonen s. Stem Cell Reports. 2019 Oct 8;13(4):669-683. doi: 10.1016/j.stemcr.2019.08.004. Epub 2019 Sep 12. Stem Cell Reports. 2019. PMID: 31522977 Free PMC article.
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids.
Fagerlund I, Dougalis A, Shakirzyanova A, Gómez-Budia M, Pelkonen A, Konttinen H, Ohtonen S, Fazaludeen MF, Koskuvi M, Kuusisto J, Hernández D, Pebay A, Koistinaho J, Rauramaa T, Lehtonen Š, Korhonen P, Malm T. Fagerlund I, et al. Among authors: ohtonen s. Cells. 2021 Dec 30;11(1):124. doi: 10.3390/cells11010124. Cells. 2021. PMID: 35011686 Free PMC article.
Microglial amyloid beta clearance is driven by PIEZO1 channels.
Jäntti H, Sitnikova V, Ishchenko Y, Shakirzyanova A, Giudice L, Ugidos IF, Gómez-Budia M, Korvenlaita N, Ohtonen S, Belaya I, Fazaludeen F, Mikhailov N, Gotkiewicz M, Ketola K, Lehtonen Š, Koistinaho J, Kanninen KM, Hernández D, Pébay A, Giugno R, Korhonen P, Giniatullin R, Malm T. Jäntti H, et al. Among authors: ohtonen s. J Neuroinflammation. 2022 Jun 15;19(1):147. doi: 10.1186/s12974-022-02486-y. J Neuroinflammation. 2022. PMID: 35706029 Free PMC article.
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function.
Ohtonen S, Giudice L, Jäntti H, Fazaludeen MF, Shakirzyanova A, Gómez-Budia M, Välimäki NN, Niskanen J, Korvenlaita N, Fagerlund I, Koistinaho J, Amiry-Moghaddam M, Savchenko E, Roybon L, Lehtonen Š, Korhonen P, Malm T. Ohtonen S, et al. Sci Rep. 2023 Dec 13;13(1):22118. doi: 10.1038/s41598-023-49294-9. Sci Rep. 2023. PMID: 38092815 Free PMC article.
Particulate matter from car exhaust alters function of human iPSC-derived microglia.
Jäntti H, Jonk S, Gómez Budia M, Ohtonen S, Fagerlund I, Fazaludeen MF, Aakko-Saksa P, Pebay A, Lehtonen Š, Koistinaho J, Kanninen KM, Jalava PI, Malm T, Korhonen P. Jäntti H, et al. Among authors: ohtonen s. Part Fibre Toxicol. 2024 Feb 15;21(1):6. doi: 10.1186/s12989-024-00564-y. Part Fibre Toxicol. 2024. PMID: 38360668 Free PMC article.