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The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
Yu S, Sun Z, Ju T, Liu Y, Mei Z, Wang C, Qu Z, Li N, Wu F, Liu K, Lu M, Huang M, Pang X, Jia Y, Li Y, Zhang Y, Dou S, Jiang J, Dong X, Huang C, Li W, Zhang Y, Yuan Y, Yang B, Du W. Yu S, et al. Among authors: jia y. Adv Sci (Weinh). 2024 Aug;11(29):e2308769. doi: 10.1002/advs.202308769. Epub 2024 May 29. Adv Sci (Weinh). 2024. PMID: 38810124 Free PMC article.
Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure.
Yu S, Sun Z, Wang X, Ju T, Wang C, Liu Y, Qu Z, Liu K, Mei Z, Li N, Lu M, Wu F, Huang M, Pang X, Jia Y, Li Y, Zhang Y, Dou S, Jiang J, Li X, Yang B, Du W. Yu S, et al. Among authors: jia y. Sci China Life Sci. 2023 Dec;66(12):2786-2804. doi: 10.1007/s11427-022-2351-1. Epub 2023 Jul 11. Sci China Life Sci. 2023. PMID: 37450238
The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury.
Qu Z, Pang X, Mei Z, Li Y, Zhang Y, Huang C, Liu K, Yu S, Wang C, Sun Z, Liu Y, Li X, Jia Y, Dong Y, Lu M, Ju T, Wu F, Huang M, Li N, Dou S, Jiang J, Dong X, Zhang Y, Li W, Yang B, Du W. Qu Z, et al. Among authors: jia y. Redox Biol. 2024 Jun;72:103145. doi: 10.1016/j.redox.2024.103145. Epub 2024 Apr 2. Redox Biol. 2024. PMID: 38583415 Free PMC article.
m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation.
Wu H, Jiang W, Pang P, Si W, Kong X, Zhang X, Xiong Y, Wang C, Zhang F, Song J, Yang Y, Zeng L, Liu K, Jia Y, Wang Z, Ju J, Diao H, Bian Y, Yang B. Wu H, et al. Among authors: jia y. Front Med. 2024 Jun;18(3):499-515. doi: 10.1007/s11684-023-1052-4. Epub 2024 May 28. Front Med. 2024. PMID: 38806989
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop.
Yu ST, Sun ZY, Li N, Qu ZZ, Wang CH, Ju TT, Liu YQ, Mei ZT, Liu KW, Lu MX, Huang M, Li Y, Dou SK, Jiang JH, Zhang YZ, Huang CH, Pang XC, Jia YQ, Dong XH, Wu F, Zhang Y, Li WH, Yang BF, Du WJ. Yu ST, et al. Among authors: jia yq. Acta Pharmacol Sin. 2024 Oct 16. doi: 10.1038/s41401-024-01395-5. Online ahead of print. Acta Pharmacol Sin. 2024. PMID: 39414959
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