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A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19.
Laura Darriba M, Castro CP, Coria LM, Bruno L, Laura Cerutti M, Otero LH, Chemes LB, Rasia RM, Klinke S, Cassataro J, Pasquevich KA. Laura Darriba M, et al. Among authors: bruno l. Comput Struct Biotechnol J. 2022 Sep 6;20:5098-5114. doi: 10.1016/j.csbj.2022.08.054. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36187929 Free PMC article.
A Brucella spp. Protease Inhibitor Limits Antigen Lysosomal Proteolysis, Increases Cross-Presentation, and Enhances CD8+ T Cell Responses.
Coria LM, Ibañez AE, Tkach M, Sabbione F, Bruno L, Carabajal MV, Berguer PM, Barrionuevo P, Schillaci R, Trevani AS, Giambartolomei GH, Pasquevich KA, Cassataro J. Coria LM, et al. Among authors: bruno l. J Immunol. 2016 May 15;196(10):4014-29. doi: 10.4049/jimmunol.1501188. Epub 2016 Apr 15. J Immunol. 2016. PMID: 27084100
A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses.
Ibañez AE, Coria LM, Carabajal MV, Delpino MV, Risso GS, Cobiello PG, Rinaldi J, Barrionuevo P, Bruno L, Frank F, Klinke S, Goldbaum FA, Briones G, Giambartolomei GH, Pasquevich KA, Cassataro J. Ibañez AE, et al. Among authors: bruno l. J Control Release. 2015 Dec 28;220(Pt A):18-28. doi: 10.1016/j.jconrel.2015.10.011. Epub 2015 Oct 9. J Control Release. 2015. PMID: 26456256 Free article.
Stability Studies of the Vaccine Adjuvant U-Omp19.
Darriba ML, Cerutti ML, Bruno L, Cassataro J, Pasquevich KA. Darriba ML, et al. Among authors: bruno l. J Pharm Sci. 2021 Feb;110(2):707-718. doi: 10.1016/j.xphs.2020.10.011. Epub 2020 Oct 12. J Pharm Sci. 2021. PMID: 33058898 Free PMC article.
A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Confers Protection Against SARS-CoV-2 Infection in Mice.
Coria LM, Saposnik LM, Pueblas Castro C, Castro EF, Bruno LA, Stone WB, Pérez PS, Darriba ML, Chemes LB, Alcain J, Mazzitelli I, Varese A, Salvatori M, Auguste AJ, Álvarez DE, Pasquevich KA, Cassataro J. Coria LM, et al. Front Immunol. 2022 Feb 28;13:844837. doi: 10.3389/fimmu.2022.844837. eCollection 2022. Front Immunol. 2022. PMID: 35296091 Free PMC article.
485 results