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Page 1
R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response.
Crossley MP, Song C, Bocek MJ, Choi JH, Kousouros JN, Sathirachinda A, Lin C, Brickner JR, Bai G, Lans H, Vermeulen W, Abu-Remaileh M, Cimprich KA. Crossley MP, et al. Nature. 2023 Jan;613(7942):187-194. doi: 10.1038/s41586-022-05545-9. Epub 2022 Dec 21. Nature. 2023. PMID: 36544021 Free PMC article.
HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability.
Bai G, Endres T, Kühbacher U, Mengoli V, Greer BH, Peacock EM, Newton MD, Stanage T, Dello Stritto MR, Lungu R, Crossley MP, Sathirachinda A, Cortez D, Boulton SJ, Cejka P, Eichman BF, Cimprich KA. Bai G, et al. Among authors: crossley mp. Mol Cell. 2024 Aug 22;84(16):3044-3060.e11. doi: 10.1016/j.molcel.2024.07.018. Epub 2024 Aug 13. Mol Cell. 2024. PMID: 39142279 Free PMC article.
AAV-mediated genome editing is influenced by the formation of R-loops.
Puzzo F, Crossley MP, Goswami A, Zhang F, Pekrun K, Garzon JL, Cimprich KA, Kay MA. Puzzo F, et al. Among authors: crossley mp. Mol Ther. 2024 Oct 5:S1525-0016(24)00660-9. doi: 10.1016/j.ymthe.2024.09.035. Online ahead of print. Mol Ther. 2024. PMID: 39369271
15 results