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Engineered CRISPR-Cas12a for higher-order combinatorial chromatin perturbations.
Hsiung CC, Wilson CM, Sambold NA, Dai R, Chen Q, Teyssier N, Misiukiewicz S, Arab A, O'Loughlin T, Cofsky JC, Shi J, Gilbert LA. Hsiung CC, et al. Among authors: arab a. Nat Biotechnol. 2024 May 17. doi: 10.1038/s41587-024-02224-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38760567
Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics.
Hsiung CC, Wilson CM, Sambold NA, Dai R, Chen Q, Misiukiewicz S, Arab A, Teyssier N, O'Loughlin T, Cofsky JC, Shi J, Gilbert LA. Hsiung CC, et al. Among authors: arab a. bioRxiv [Preprint]. 2024 Feb 9:2023.09.18.558350. doi: 10.1101/2023.09.18.558350. bioRxiv. 2024. Update in: Nat Biotechnol. 2024 May 17. doi: 10.1038/s41587-024-02224-0. PMID: 37781594 Free PMC article. Updated. Preprint.
Functional microRNA-targeting drug discovery by graph-based deep learning.
Keshavarzi Arshadi A, Salem M, Karner H, Garcia K, Arab A, Yuan JS, Goodarzi H. Keshavarzi Arshadi A, et al. Among authors: arab a. Patterns (N Y). 2024 Jan 3;5(1):100909. doi: 10.1016/j.patter.2023.100909. eCollection 2024 Jan 12. Patterns (N Y). 2024. PMID: 38264717 Free PMC article.
PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity.
Furuya H, Sasaki Y, Chen R, Peres R, Hokutan K, Murakami K, Kim N, Chan OTM, Pagano I, Dyrskjøt L, Jensen JB, Malmstrom PU, Segersten U, Sun Y, Arab A, Goodarzi H, Goodison S, Rosser CJ. Furuya H, et al. Among authors: arab a. Sci Rep. 2022 Jul 16;12(1):12186. doi: 10.1038/s41598-022-16518-3. Sci Rep. 2022. PMID: 35842542 Free PMC article.
Propagated Circulating Tumor Cells Uncover the Potential Role of NFκB, EMT, and TGFβ Signaling Pathways and COP1 in Metastasis.
Xiao J, Sharma U, Arab A, Miglani S, Bhalla S, Suguru S, Suter R, Mukherji R, Lippman ME, Pohlmann PR, Zeck JC, Marshall JL, Weinberg BA, He AR, Noel MS, Schlegel R, Goodarzi H, Agarwal S. Xiao J, et al. Among authors: arab a. Cancers (Basel). 2023 Mar 17;15(6):1831. doi: 10.3390/cancers15061831. Cancers (Basel). 2023. PMID: 36980717 Free PMC article.
Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy.
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel AK, Okoye M, Scantlen MD, Tchieu J, Calder EL, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis JD, Chen S, Studer L, Fattahi F. Majd H, et al. Among authors: arab a. Cell Stem Cell. 2023 May 4;30(5):632-647.e10. doi: 10.1016/j.stem.2023.04.006. Cell Stem Cell. 2023. PMID: 37146583 Free PMC article.
372 results