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The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells.
López-Gil JC, García-Silva S, Ruiz-Cañas L, Navarro D, Palencia-Campos A, Giráldez-Trujillo A, Earl J, Dorado J, Gómez-López G, Monfort-Vengut A, Alcalá S, Gaida MM, García-Mulero S, Cabezas-Sáinz P, Batres-Ramos S, Barreto E, Sánchez-Tomero P, Vallespinós M, Ambler L, Lin ML, Aicher A, García García de Paredes A, de la Pinta C, Sanjuanbenito A, Ruz-Caracuel I, Rodríguez-Garrote M, Guerra C, Carrato A, de Cárcer G, Sánchez L, Nombela-Arrieta C, Espinet E, Sanchez-Arevalo Lobo VJ, Heeschen C, Sainz B Jr. López-Gil JC, et al. Among authors: aicher a. Gut. 2024 Aug 8;73(9):1489-1508. doi: 10.1136/gutjnl-2023-330995. Gut. 2024. PMID: 38754953 Free PMC article.
Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice.
Skeltved N, Nordmaj MA, Berendtsen NT, Dagil R, Stormer EMR, Al-Nakouzi N, Jiang K, Aicher A, Heeschen C, Gustavsson T, Choudhary S, Gögenur I, Christensen JP, Theander TG, Daugaard M, Salanti A, Nielsen MA. Skeltved N, et al. Among authors: aicher a. J Exp Clin Cancer Res. 2023 Apr 28;42(1):106. doi: 10.1186/s13046-023-02655-8. J Exp Clin Cancer Res. 2023. PMID: 37118819 Free PMC article.
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity.
Zheng Q, Tang J, Aicher A, Bou Kheir T, Sabanovic B, Ananthanarayanan P, Reina C, Chen M, Gu JM, He B, Alcala S, Behrens D, Lawlo RT, Scarpa A, Hidalgo M, Sainz B Jr, Sancho P, Heeschen C. Zheng Q, et al. Among authors: aicher a. J Exp Clin Cancer Res. 2023 Nov 28;42(1):323. doi: 10.1186/s13046-023-02883-y. J Exp Clin Cancer Res. 2023. PMID: 38012687 Free PMC article.
CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches.
Tang J, Zheng Q, Wang Q, Zhao Y, Ananthanarayanan P, Reina C, Šabanović B, Jiang K, Yang MH, Meny CC, Wang H, Agerbaek MØ, Clausen TM, Gustavsson T, Wen C, Borghi F, Mellano A, Fenocchio E, Gregorc V, Sapino A, Theander TG, Fu D, Aicher A, Salanti A, Shen B, Heeschen C. Tang J, et al. Among authors: aicher a. Cell Rep Med. 2024 Sep 17;5(9):101692. doi: 10.1016/j.xcrm.2024.101692. Epub 2024 Aug 19. Cell Rep Med. 2024. PMID: 39163864 Free PMC article.
Gasdermin C promotes Stemness and Immune Evasion in Pancreatic Cancer via Pyroptosis-Independent Mechanism.
Wu R, Li J, Aicher A, Jiang K, Tondi S, Dong S, Zheng Q, Tang S, Chen M, Guo Z, Šabanović B, Ananthanarayanan P, Jiang L, Sapino A, Wen C, Fu D, Shen B, Heeschen C. Wu R, et al. Among authors: aicher a. Adv Sci (Weinh). 2024 Nov;11(42):e2308990. doi: 10.1002/advs.202308990. Epub 2024 Sep 19. Adv Sci (Weinh). 2024. PMID: 39297408 Free PMC article.
87 results