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Pharmacokinetic-pharmacodynamic (dipeptidyl peptidase-4 inhibition) model to support dose rationale in diabetes patients, including those with renal impairment, for once-weekly administered omarigliptin.
Jain L, Chain ASY, Tatosian DA, Hing J, Passarell JA, Kauh EA, Lai E. Jain L, et al. Among authors: chain asy. Br J Clin Pharmacol. 2019 Dec;85(12):2759-2771. doi: 10.1111/bcp.14103. Epub 2019 Dec 9. Br J Clin Pharmacol. 2019. PMID: 31454094 Free PMC article.
Population pharmacokinetic analyses for belzutifan to inform dosing considerations and labeling.
Marathe DD, Jauslin PM, Kleijn HJ, de Miranda Silva C, Chain A, Bateman T, Shaw PM, Abraham AK, Kauh EA, Liu Y, Perini RF, de Alwis DP, Jain L. Marathe DD, et al. Among authors: chain a. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1499-1510. doi: 10.1002/psp4.13028. Epub 2023 Aug 28. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37596839 Free PMC article.
Immunogenicity of pembrolizumab in patients with advanced tumors.
van Vugt MJH, Stone JA, De Greef RHJMM, Snyder ES, Lipka L, Turner DC, Chain A, Lala M, Li M, Robey SH, Kondic AG, De Alwis D, Mayawala K, Jain L, Freshwater T. van Vugt MJH, et al. Among authors: chain a. J Immunother Cancer. 2019 Aug 8;7(1):212. doi: 10.1186/s40425-019-0663-4. J Immunother Cancer. 2019. PMID: 31395089 Free PMC article.
Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.
Morissette P, Polak S, Chain A, Zhai J, Imredy JP, Wildey MJ, Travis J, Fitzgerald K, Fanelli P, Passini E, Rodriguez B, Sannajust F, Regan C. Morissette P, et al. Among authors: chain a. Toxicol Appl Pharmacol. 2020 Mar 1;390:114883. doi: 10.1016/j.taap.2020.114883. Epub 2020 Jan 23. Toxicol Appl Pharmacol. 2020. PMID: 31981640 Free PMC article.
Raltegravir (RAL) in Neonates: Dosing, Pharmacokinetics (PK), and Safety in HIV-1-Exposed Neonates at Risk of Infection (IMPAACT P1110).
Clarke DF, Acosta EP, Cababasay M, Wang J, Chain A, Teppler H, Popson S, Graham B, Smith B, Hazra R, Calabrese K, Bryson Y, Spector SA, Lommerse J, Mirochnick M; IMPAACT P1110 Protocol Team. Clarke DF, et al. Among authors: chain a. J Acquir Immune Defic Syndr. 2020 May 1;84(1):70-77. doi: 10.1097/QAI.0000000000002294. J Acquir Immune Defic Syndr. 2020. PMID: 31913995 Free PMC article. Clinical Trial.
Use of Modeling and Simulations to Determine Raltegravir Dosing in Neonates: A Model for Safely and Efficiently Determining Appropriate Neonatal Dosing Regimens: IMPAACT P1110.
Clarke DF, Mirochnick M, Acosta EP, Capparelli E, Chain A, Teppler H, Smith B, Lommerse J; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1110 Study Team. Clarke DF, et al. Among authors: chain a. J Acquir Immune Defic Syndr. 2019 Dec 1;82(4):392-398. doi: 10.1097/QAI.0000000000002149. J Acquir Immune Defic Syndr. 2019. PMID: 31658182 Free PMC article.
Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.
Nayak S, Sander O, Al-Huniti N, de Alwis D, Chain A, Chenel M, Sunkaraneni S, Agrawal S, Gupta N, Visser SAG. Nayak S, et al. Among authors: chain a. Clin Pharmacol Ther. 2018 Mar;103(3):378-383. doi: 10.1002/cpt.978. Epub 2018 Jan 13. Clin Pharmacol Ther. 2018. PMID: 29330855 Free PMC article.
37 results