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Page 1
CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant.
Kaplan SJ, Wong W, Yan J, Pulecio J, Cho HS, Li Q, Zhao J, Leslie-Iyer J, Kazakov J, Murphy D, Luo R, Dey KK, Apostolou E, Leslie CS, Huangfu D. Kaplan SJ, et al. Among authors: apostolou e. bioRxiv [Preprint]. 2024 Jun 28:2024.04.26.591412. doi: 10.1101/2024.04.26.591412. bioRxiv. 2024. Update in: Cell Rep. 2024 Aug 27;43(8):114640. doi: 10.1016/j.celrep.2024.114640. PMID: 38746154 Free PMC article. Updated. Preprint.
Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions.
Luo R, Yan J, Oh JW, Xi W, Shigaki D, Wong W, Cho H, Murphy D, Cutler R, Rosen BP, Pulecio J, Yang D, Glenn R, Chen T, Li QV, Vierbuchen T, Sidoli S, Apostolou E, Huangfu D, Beer MA. Luo R, et al. Among authors: apostolou e. bioRxiv [Preprint]. 2023 Mar 9:2023.03.07.531569. doi: 10.1101/2023.03.07.531569. bioRxiv. 2023. Update in: Nat Genet. 2023 Aug;55(8):1336-1346. doi: 10.1038/s41588-023-01450-7. PMID: 36945628 Free PMC article. Updated. Preprint.
Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities.
Garg V, Yang Y, Nowotschin S, Setty M, Kuo YY, Sharma R, Polyzos A, Salataj E, Murphy D, Jang A, Pe'er D, Apostolou E, Hadjantonakis AK. Garg V, et al. Among authors: apostolou e. bioRxiv [Preprint]. 2023 Mar 29:2023.03.28.534648. doi: 10.1101/2023.03.28.534648. bioRxiv. 2023. PMID: 37034770 Free PMC article. Preprint.
Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells.
Pulecio J, Tayyebi Z, Liu D, Wong W, Luo R, Damodaran JR, Kaplan S, Cho H, Yan J, Murphy D, Rickert RW, Shukla A, Zhong A, González F, Yang D, Li W, Zhou T, Apostolou E, Leslie CS, Huangfu D. Pulecio J, et al. Among authors: apostolou e. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544990. doi: 10.1101/2023.06.14.544990. bioRxiv. 2023. PMID: 37398096 Free PMC article. Preprint.
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility.
Gao VR, Yang R, Das A, Luo R, Luo H, McNally DR, Karagiannidis I, Rivas MA, Wang ZM, Barisic D, Karbalayghareh A, Wong W, Zhan YA, Chin CR, Noble W, Bilmes JA, Apostolou E, Kharas MG, Béguelin W, Viny AD, Huangfu D, Rudensky AY, Melnick AM, Leslie CS. Gao VR, et al. Among authors: apostolou e. bioRxiv [Preprint]. 2023 Jul 28:2023.07.27.550836. doi: 10.1101/2023.07.27.550836. bioRxiv. 2023. Update in: Nat Commun. 2024 Nov 1;15(1):9432. doi: 10.1038/s41467-024-53628-0. PMID: 37546906 Free PMC article. Updated. Preprint.
Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression.
Murphy D, Salataj E, Di Giammartino DC, Rodriguez-Hernaez J, Kloetgen A, Garg V, Char E, Uyehara CM, Ee LS, Lee U, Stadtfeld M, Hadjantonakis AK, Tsirigos A, Polyzos A, Apostolou E. Murphy D, et al. Among authors: apostolou e. bioRxiv [Preprint]. 2023 Jul 19:2023.07.19.549714. doi: 10.1101/2023.07.19.549714. bioRxiv. 2023. PMID: 37577543 Free PMC article. Preprint.
TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer.
Wong EWP, Sahin M, Yang R, Lee U, Zhan YA, Misra R, Tomas F, Alomran N, Polyzos A, Lee CJ, Trieu T, Fundichely AM, Wiesner T, Rosowicz A, Cheng S, Liu C, Lallo M, Merghoub T, Hamard PJ, Koche R, Khurana E, Apostolou E, Zheng D, Chen Y, Leslie CS, Chi P. Wong EWP, et al. Among authors: apostolou e. bioRxiv [Preprint]. 2024 Jun 3:2024.05.31.596845. doi: 10.1101/2024.05.31.596845. bioRxiv. 2024. PMID: 38895201 Free PMC article. Preprint.
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naïve pluripotent stem cells.
Parikh C, Glenn RA, Shi Y, Chatterjee K, Swanzey EE, Singer S, Do SC, Zhan Y, Furuta Y, Tahiliani M, Apostolou E, Polyzos A, Koche R, Mezey JG, Vierbuchen T, Stadtfeld M. Parikh C, et al. Among authors: apostolou e. bioRxiv [Preprint]. 2024 Jun 30:2024.06.26.600805. doi: 10.1101/2024.06.26.600805. bioRxiv. 2024. PMID: 38979237 Free PMC article. Preprint.
83 results