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On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. Among authors: malcolm tr. mBio. 2024 Jun 12;15(6):e0096624. doi: 10.1128/mbio.00966-24. Epub 2024 May 8. mBio. 2024. PMID: 38717141 Free PMC article.
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
Creek D, Giannangelo C, Challis M, Siddiqui G, Edgar R, Malcolm T, Webb C, Drinkwater N, Vinh N, MacRaild C, Counihan N, Duffy S, Wittlin S, Devine S, Avery V, de Koning-Ward T, Scammells P, McGowan S. Creek D, et al. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-3251230. doi: 10.21203/rs.3.rs-3251230/v3. Res Sq. 2024. Update in: Elife. 2024 Jul 08;13:RP92990. doi: 10.7554/eLife.92990. PMID: 38746424 Free PMC article. Updated. Preprint.
23 results