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Page 1
Design of allosteric modulators that change GPCR G protein subtype selectivity.
Moore MN, Person KL, Alwin A, Krusemark C, Foster N, Ray C, Inoue A, Jackson MR, Sheedlo MJ, Barak LS, Fernandez de Velasco EM, Olson SH, Slosky LM. Moore MN, et al. Among authors: barak ls. bioRxiv [Preprint]. 2024 Nov 21:2024.11.20.624209. doi: 10.1101/2024.11.20.624209. bioRxiv. 2024. PMID: 39605353 Free PMC article. Preprint.
Nonlinear progression during the occult transition establishes cancer lethality.
Ginzel JD, Chapman H, Sills JE, Allen EJ, Barak LS, Cardiff RD, Borowsky AD, Lyerly HK, Rogers BW, Snyder JC. Ginzel JD, et al. Among authors: barak ls. bioRxiv [Preprint]. 2024 Aug 12:2024.04.23.590826. doi: 10.1101/2024.04.23.590826. bioRxiv. 2024. PMID: 38712192 Free PMC article. Preprint.
β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents.
Gereau GB, Zhou D, Van Voorhies K, Tyler RE, Campbell J, Murray JG, Alvarez-Pamir A, Wykoff LA, Companion MA, Jackson MR, Olson SH, Barak LS, Slosky LM, Vetreno RP, Besheer J, McElligott ZA. Gereau GB, et al. Among authors: barak ls. bioRxiv [Preprint]. 2024 Apr 13:2024.04.10.588903. doi: 10.1101/2024.04.10.588903. bioRxiv. 2024. PMID: 38645173 Free PMC article. Preprint.
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL. Krumm BE, et al. Among authors: barak ls. Biochemistry. 2023 Apr 4;62(7):1233-1248. doi: 10.1021/acs.biochem.3c00029. Epub 2023 Mar 14. Biochemistry. 2023. PMID: 36917754
Ghrelin receptor signaling in health and disease: a biased view.
Gross JD, Zhou Y, Barak LS, Caron MG. Gross JD, et al. Among authors: barak ls. Trends Endocrinol Metab. 2023 Feb;34(2):106-118. doi: 10.1016/j.tem.2022.12.001. Epub 2022 Dec 24. Trends Endocrinol Metab. 2023. PMID: 36567228 Free PMC article. Review.
Establishment of multi-stage intravenous self-administration paradigms in mice.
Slosky LM, Pires A, Bai Y, Clark NB, Hauser ER, Gross JD, Porkka F, Zhou Y, Chen X, Pogorelov VM, Toth K, Wetsel WC, Barak LS, Caron MG. Slosky LM, et al. Among authors: barak ls. Sci Rep. 2022 Dec 11;12(1):21422. doi: 10.1038/s41598-022-24740-2. Sci Rep. 2022. PMID: 36503898 Free PMC article.
Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine.
Gross JD, Kim DW, Zhou Y, Jansen D, Slosky LM, Clark NB, Ray CR, Hu X, Southall N, Wang A, Xu X, Barnaeva E, Wetsel WC, Ferrer M, Marugan JJ, Caron MG, Barak LS, Toth K. Gross JD, et al. Among authors: barak ls. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2112397119. doi: 10.1073/pnas.2112397119. Epub 2022 Mar 3. Proc Natl Acad Sci U S A. 2022. PMID: 35239443 Free PMC article.
HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase.
Ginzel JD, Acharya CR, Lubkov V, Mori H, Boone PG, Rochelle LK, Roberts WL, Everitt JI, Hartman ZC, Crosby EJ, Barak LS, Caron MG, Chen JQ, Hubbard NE, Cardiff RD, Borowsky AD, Lyerly HK, Snyder JC. Ginzel JD, et al. Among authors: barak ls. Mol Cancer Res. 2021 Oct;19(10):1699-1711. doi: 10.1158/1541-7786.MCR-21-0215. Epub 2021 Jun 15. Mol Cancer Res. 2021. PMID: 34131071 Free PMC article.
Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery.
Slosky LM, Caron MG, Barak LS. Slosky LM, et al. Among authors: barak ls. Trends Pharmacol Sci. 2021 Apr;42(4):283-299. doi: 10.1016/j.tips.2020.12.005. Epub 2021 Feb 10. Trends Pharmacol Sci. 2021. PMID: 33581873 Free PMC article. Review.
133 results