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Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration.
Lee S, Vander Roest AS, Blair CA, Kao K, Bremner SB, Childers MC, Pathak D, Heinrich P, Lee D, Chirikian O, Mohran SE, Roberts B, Smith JE, Jahng JW, Paik DT, Wu JC, Gunawardane RN, Ruppel KM, Mack DL, Pruitt BL, Regnier M, Wu SM, Spudich JA, Bernstein D. Lee S, et al. Among authors: pathak d. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318413121. doi: 10.1073/pnas.2318413121. Epub 2024 Apr 29. Proc Natl Acad Sci U S A. 2024. PMID: 38683993 Free PMC article.
Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration.
Lee S, Roest ASV, Blair CA, Kao K, Bremner SB, Childers MC, Pathak D, Heinrich P, Lee D, Chirikian O, Mohran S, Roberts B, Smith JE, Jahng JW, Paik DT, Wu JC, Gunawardane RN, Spudich JA, Ruppel K, Mack D, Pruitt BL, Regnier M, Wu SM, Bernstein D. Lee S, et al. Among authors: pathak d. bioRxiv [Preprint]. 2023 Jun 9:2023.06.08.544276. doi: 10.1101/2023.06.08.544276. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318413121. doi: 10.1073/pnas.2318413121. PMID: 37333118 Free PMC article. Updated. Preprint.
Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy.
Suay-Corredera C, Pricolo MR, Velázquez-Carreras D, Pathak D, Nandwani N, Pimenta-Lopes C, Sánchez-Ortiz D, Urrutia-Irazabal I, Vilches S, Dominguez F, Frisso G, Monserrat L, García-Pavía P, de Sancho D, Spudich JA, Ruppel KM, Herrero-Galán E, Alegre-Cebollada J. Suay-Corredera C, et al. Among authors: pathak d. ACS Nano. 2021 Jun 22;15(6):10203-10216. doi: 10.1021/acsnano.1c02242. Epub 2021 Jun 1. ACS Nano. 2021. PMID: 34060810 Free PMC article.
Cryo-EM structure of the folded-back state of human β-cardiac myosin.
Grinzato A, Auguin D, Kikuti C, Nandwani N, Moussaoui D, Pathak D, Kandiah E, Ruppel KM, Spudich JA, Houdusse A, Robert-Paganin J. Grinzato A, et al. Among authors: pathak d. Nat Commun. 2023 May 31;14(1):3166. doi: 10.1038/s41467-023-38698-w. Nat Commun. 2023. PMID: 37258552 Free PMC article.
Cryo-EM structure of the folded-back state of human β-cardiac myosin.
Grinzato A, Auguin D, Kikuti C, Nandwani N, Moussaoui D, Pathak D, Kandiah E, Ruppel KM, Spudich JA, Houdusse A, Robert-Paganin J. Grinzato A, et al. Among authors: pathak d. bioRxiv [Preprint]. 2023 Apr 18:2023.04.15.536999. doi: 10.1101/2023.04.15.536999. bioRxiv. 2023. Update in: Nat Commun. 2023 May 31;14(1):3166. doi: 10.1038/s41467-023-38698-w. PMID: 37131793 Free PMC article. Updated. Preprint.
602 results