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Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
Chen Z, Guo X, Tao R, Huyghe JR, Law PJ, Fernandez-Rozadilla C, Ping J, Jia G, Long J, Li C, Shen Q, Xie Y, Timofeeva MN, Thomas M, Schmit SL, Díez-Obrero V, Devall M, Moratalla-Navarro F, Fernandez-Tajes J, Palles C, Sherwood K, Briggs SEW, Svinti V, Donnelly K, Farrington SM, Blackmur J, Vaughan-Shaw PG, Shu XO, Lu Y, Broderick P, Studd J, Harrison TA, Conti DV, Schumacher FR, Melas M, Rennert G, Obón-Santacana M, Martín-Sánchez V, Oh JH, Kim J, Jee SH, Jung KJ, Kweon SS, Shin MH, Shin A, Ahn YO, Kim DH, Oze I, Wen W, Matsuo K, Matsuda K, Tanikawa C, Ren Z, Gao YT, Jia WH, Hopper JL, Jenkins MA, Win AK, Pai RK, Figueiredo JC, Haile RW, Gallinger S, Woods MO, Newcomb PA, Duggan D, Cheadle JP, Kaplan R, Kerr R, Kerr D, Kirac I, Böhm J, Mecklin JP, Jousilahti P, Knekt P, Aaltonen LA, Rissanen H, Pukkala E, Eriksson JG, Cajuso T, Hänninen U, Kondelin J, Palin K, Tanskanen T, Renkonen-Sinisalo L, Männistö S, Albanes D, Weinstein SJ, Ruiz-Narvaez E, Palmer JR, Buchanan DD, Platz EA, Visvanathan K, Ulrich CM, Siegel E, Brezina S, Gsur A, Campbell PT, Chang-Claude J, Hoffmeister M, Brenner H, Slattery ML, Potter JD, Tsilidis KK, Schulze MB, Gunter MJ, Murphy N, Castells A, Castel… See abstract for full author list ➔ Chen Z, et al. Among authors: pai rk. Nat Commun. 2024 Apr 26;15(1):3557. doi: 10.1038/s41467-024-47399-x. Nat Commun. 2024. PMID: 38670944 Free PMC article.
Rare Variants in the DNA Repair Pathway and the Risk of Colorectal Cancer.
Matejcic M, Shaban HA, Quintana MW, Schumacher FR, Edlund CK, Naghi L, Pai RK, Haile RW, Levine AJ, Buchanan DD, Jenkins MA, Figueiredo JC, Rennert G, Gruber SB, Li L, Casey G, Conti DV, Schmit SL. Matejcic M, et al. Among authors: pai rk. Cancer Epidemiol Biomarkers Prev. 2021 May;30(5):895-903. doi: 10.1158/1055-9965.EPI-20-1457. Epub 2021 Feb 24. Cancer Epidemiol Biomarkers Prev. 2021. PMID: 33627384 Free PMC article.
Assessment of a Polygenic Risk Score for Colorectal Cancer to Predict Risk of Lynch Syndrome Colorectal Cancer.
Jenkins MA, Buchanan DD, Lai J, Makalic E, Dite GS, Win AK, Clendenning M, Winship IM, Hayes RB, Huyghe JR, Peters U, Gallinger S, Marchand LL, Figueiredo JC, Pai RK, Newcomb PA, Church JM, Casey G, Hopper JL. Jenkins MA, et al. Among authors: pai rk. JNCI Cancer Spectr. 2021 Mar 8;5(2):pkab022. doi: 10.1093/jncics/pkab022. eCollection 2021 Apr. JNCI Cancer Spectr. 2021. PMID: 33928216 Free PMC article.
Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study.
Hua X, Dai JY, Lindström S, Harrison TA, Lin Y, Alberts SR, Alwers E, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Casey G, Chang-Claude J, Gallinger S, Giles GG, Goldberg RM, Gunter MJ, Hoffmeister M, Jenkins MA, Joshi AD, Ma W, Milne RL, Murphy N, Pai RK, Sakoda LC, Schoen RE, Shi Q, Slattery ML, Song M, White E, Marchand LL, Chan AT, Peters U, Newcomb PA. Hua X, et al. Among authors: pai rk. Cancer Epidemiol Biomarkers Prev. 2021 Jul;30(7):1349-1358. doi: 10.1158/1055-9965.EPI-20-1848. Epub 2021 May 10. Cancer Epidemiol Biomarkers Prev. 2021. PMID: 33972368 Free PMC article.
Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer.
Archambault AN, Lin Y, Jeon J, Harrison TA, Bishop DT, Brenner H, Casey G, Chan AT, Chang-Claude J, Figueiredo JC, Gallinger S, Gruber SB, Gunter MJ, Hoffmeister M, Jenkins MA, Keku TO, Marchand LL, Li L, Moreno V, Newcomb PA, Pai R, Parfrey PS, Rennert G, Sakoda LC, Sandler RS, Slattery ML, Song M, Win AK, Woods MO, Murphy N, Campbell PT, Su YR, Zeleniuch-Jacquotte A, Liang PS, Du M, Hsu L, Peters U, Hayes RB. Archambault AN, et al. JNCI Cancer Spectr. 2021 May 20;5(3):pkab029. doi: 10.1093/jncics/pkab029. eCollection 2021 Jun. JNCI Cancer Spectr. 2021. PMID: 34041438 Free PMC article.
A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients.
Wills C, He Y, Summers MG, Lin Y, Phipps AI, Watts K, Law PJ, Al-Tassan NA, Maughan TS, Kaplan R, Houlston RS, Peters U, Newcomb PA, Chan AT, Buchanan DD, Gallinger S, Marchand LL, Pai RK, Shi Q, Alberts SR, Gray V, West HD, Escott-Price V, Dunlop MG, Cheadle JP. Wills C, et al. Among authors: pai rk. Eur J Cancer. 2021 Dec;159:247-258. doi: 10.1016/j.ejca.2021.09.047. Epub 2021 Nov 15. Eur J Cancer. 2021. PMID: 34794066 Free PMC article.
Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex-specific and lifestyle factors specific associations.
Huang Y, Hua X, Labadie JD, Harrison TA, Dai JY, Lindstrom S, Lin Y, Berndt SI, Buchanan DD, Campbell PT, Casey G, Gallinger SJ, Gunter MJ, Hoffmeister M, Jenkins MA, Sakoda LC, Schoen RE, Diergaarde B, Slattery ML, White E, Giles G, Brenner H, Chang-Claude J, Joshi A, Ma W, Pai RK, Chan AT, Peters U, Newcomb PA. Huang Y, et al. Among authors: pai rk. Int J Cancer. 2022 May 1;150(9):1447-1454. doi: 10.1002/ijc.33897. Epub 2022 Jan 13. Int J Cancer. 2022. PMID: 34888857 Free PMC article.
363 results