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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
Karim M, Mishra M, Lo CW, Saul S, Cagirici HB, Tran DHN, Agrawal A, Ghita L, Ojha A, East MP, Gammeltoft KA, Sahoo MK, Johnson GL, Das S, Jochmans D, Cohen CA, Gottwein J, Dye J, Neff N, Pinsky BA, Laitinen T, Pantsar T, Poso A, Zanini F, Jonghe S, Asquith CRM, Einav S. Karim M, et al. Among authors: einav s. bioRxiv [Preprint]. 2024 Apr 17:2024.04.15.589676. doi: 10.1101/2024.04.15.589676. bioRxiv. 2024. PMID: 38659941 Free PMC article. Preprint.
Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.
Saul S, Karim M, Ghita L, Huang PT, Chiu W, Durán V, Lo CW, Kumar S, Bhalla N, Leyssen P, Alem F, Boghdeh NA, Tran DH, Cohen CA, Brown JA, Huie KE, Tindle C, Sibai M, Ye C, Khalil AM, Martinez-Sobrido L, Dye JM, Pinsky BA, Ghosh P, Das S, Solow-Cordero DE, Jin J, Wikswo JP, Jochmans D, Neyts J, Jonghe S, Narayanan A, Einav S. Saul S, et al. Among authors: einav s. bioRxiv [Preprint]. 2023 May 10:2021.05.15.444128. doi: 10.1101/2021.05.15.444128. bioRxiv. 2023. Update in: J Clin Invest. 2023 Oct 2;133(19):e169510. doi: 10.1172/JCI169510. PMID: 34159337 Free PMC article. Updated. Preprint.
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T. Gerninghaus J, et al. Among authors: einav s. bioRxiv [Preprint]. 2024 Feb 18:2024.02.18.580805. doi: 10.1101/2024.02.18.580805. bioRxiv. 2024. Update in: J Med Chem. 2024 Aug 8;67(15):12534-12552. doi: 10.1021/acs.jmedchem.4c00411. PMID: 38405908 Free PMC article. Updated. Preprint.
Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.
Lubow J, Levoir LM, Ralph DK, Belmont L, Contreras M, Cartwright-Acar CH, Kikawa C, Kannan S, Davidson E, Doranz BJ, Duran V, Sanchez DE, Sanz AM, Rosso F, Einav S, Matsen FA, Goo L. Lubow J, et al. Among authors: einav s. bioRxiv [Preprint]. 2023 Apr 10:2023.04.09.536175. doi: 10.1101/2023.04.09.536175. bioRxiv. 2023. Update in: PLoS Pathog. 2023 Oct 9;19(10):e1011722. doi: 10.1371/journal.ppat.1011722. PMID: 37090561 Free PMC article. Updated. Preprint.
Intensive care for the long-term.
Einav S. Einav S. Curr Opin Crit Care. 2024 Oct 1;30(5):470-471. doi: 10.1097/MCC.0000000000001195. Epub 2024 Sep 5. Curr Opin Crit Care. 2024. PMID: 39246161 No abstract available.
Using augmented intelligence to improve long term outcomes.
Zahavi I, Ben Shitrit I, Einav S. Zahavi I, et al. Among authors: einav s. Curr Opin Crit Care. 2024 Oct 1;30(5):523-531. doi: 10.1097/MCC.0000000000001185. Curr Opin Crit Care. 2024. PMID: 39150034 Review.
461 results