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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Ferretti S, Hamon J, de Kanter R, Scheufler C, Andraos-Rey R, Barbe S, Bechter E, Blank J, Bordas V, Dammassa E, Decker A, Di Nanni N, Dourdoigne M, Gavioli E, Hattenberger M, Heuser A, Hemmerlin C, Hinrichs J, Kerr G, Laborde L, Jaco I, Núñez EJ, Martus HJ, Quadt C, Reschke M, Romanet V, Schaeffer F, Schoepfer J, Schrapp M, Strang R, Voshol H, Wartmann M, Welly S, Zécri F, Hofmann F, Möbitz H, Cortés-Cros M. Ferretti S, et al. Nature. 2024 May;629(8011):443-449. doi: 10.1038/s41586-024-07350-y. Epub 2024 Apr 24. Nature. 2024. PMID: 38658754 Free PMC article.
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.
Cortés-Cros M, Hemmerlin C, Ferretti S, Zhang J, Gounarides JS, Yin H, Muller A, Haberkorn A, Chene P, Sellers WR, Hofmann F. Cortés-Cros M, et al. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):489-94. doi: 10.1073/pnas.1212780110. Epub 2012 Dec 24. Proc Natl Acad Sci U S A. 2013. PMID: 23267074 Free PMC article.
A plastid-localized bona fide geranylgeranyl diphosphate synthase plays a necessary role in monoterpene indole alkaloid biosynthesis in Catharanthus roseus.
Kumar SR, Rai A, Bomzan DP, Kumar K, Hemmerlin A, Dwivedi V, Godbole RC, Barvkar V, Shanker K, Shilpashree HB, Bhattacharya A, Smitha AR, Hegde N, Nagegowda DA. Kumar SR, et al. Plant J. 2020 Jul;103(1):248-265. doi: 10.1111/tpj.14725. Epub 2020 Apr 10. Plant J. 2020. PMID: 32064705 Free article.
In plants, geranylgeranyl diphosphate (GGPP, C(20) ) synthesized by GGPP synthase (GGPPS) serves as precursor for vital metabolic branches including specialized metabolites. Here, we report the characterization of a GGPPS (CrGGPPS2) from the Madagascar periwinkle (Catharan …
In plants, geranylgeranyl diphosphate (GGPP, C(20) ) synthesized by GGPP synthase (GGPPS) serves as precursor for vital metabolic bra …
Plant isoprenoid biosynthesis via the MEP pathway: in vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures.
Tritsch D, Hemmerlin A, Bach TJ, Rohmer M. Tritsch D, et al. FEBS Lett. 2010 Jan 4;584(1):129-34. doi: 10.1016/j.febslet.2009.11.010. FEBS Lett. 2010. PMID: 19903472 Free article.
Feeding tobacco BY-2 cells with [2-(13)C,4-(2)H]deoxyxylulose revealed from the (13)C labeling that the plastid isoprenoids, synthesized via the MEP pathway, are essentially derived from the labeled precursor. ...
Feeding tobacco BY-2 cells with [2-(13)C,4-(2)H]deoxyxylulose revealed from the (13)C labeling that the plastid isoprenoids, s …
Characterisation of the gene family encoding acetoacetyl-CoA thiolase in Arabidopsis.
Ahumada I, Cairó A, Hemmerlin A, González V, Pateraki I, Bach TJ, Rodríguez-Concepción M, Campos N, Boronat A. Ahumada I, et al. Funct Plant Biol. 2008 Dec;35(11):1100-1111. doi: 10.1071/FP08012. Funct Plant Biol. 2008. PMID: 32688858
The peroxisomal localisation of AACT1 depends on the presence of a C-terminal peroxisomal targeting sequence (PTS1) motif (Ser-Ala-Leu) not previously found in other organisms. ...
The peroxisomal localisation of AACT1 depends on the presence of a C-terminal peroxisomal targeting sequence (PTS1) motif (Ser-Ala-Le …
Monitoring farnesol-induced toxicity in tobacco BY-2 cells with a fluorescent analog.
Hemmerlin A, Reents R, Mutterer J, Feldtrauer JF, Waldmann H, Bach TJ. Hemmerlin A, et al. Arch Biochem Biophys. 2006 Apr 15;448(1-2):93-103. doi: 10.1016/j.abb.2005.10.017. Epub 2005 Nov 9. Arch Biochem Biophys. 2006. PMID: 16307722
In a previous study (A. Hemmerlin, T.J. Bach, Plant Physiol. 123 (2000) 1257-1268), we have demonstrated that above a critical concentration, treatment with all-trans-farnesol induces cell-death in Nicotiana tabacum L. cv Bright Yellow-2 (TBY-2) cells. ...
In a previous study (A. Hemmerlin, T.J. Bach, Plant Physiol. 123 (2000) 1257-1268), we have demonstrated that above a critical concen …
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