Sheng C - Search Results

1

Targeting the undruggables-the power of protein degraders.

Zhang C, Liu Y, Li G, Yang Z, Han C, Sun X, Sheng C, Ding K, Rao Y. Zhang C, et al. Among authors: sheng c. Sci Bull (Beijing). 2024 Jun 15;69(11):1776-1797. doi: 10.1016/j.scib.2024.03.056. Epub 2024 Mar 29. Sci Bull (Beijing). 2024. PMID: 38614856 Free article. Review.

2

One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp³)-H activations.

Yang X, Shan G, Yang Z, Huang G, Dong G, Sheng C, Rao Y. Yang X, et al. Among authors: sheng c. Chem Commun (Camb). 2017 Jan 26;53(9):1534-1537. doi: 10.1039/c6cc06897a. Chem Commun (Camb). 2017. PMID: 28093588

3

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.

Dong G, Chen W, Wang X, Yang X, Xu T, Wang P, Zhang W, Rao Y, Miao C, Sheng C. Dong G, et al. Among authors: sheng c. J Med Chem. 2017 Oct 12;60(19):7965-7983. doi: 10.1021/acs.jmedchem.7b00467. Epub 2017 Sep 21. J Med Chem. 2017. PMID: 28885834

4

Stimuli-activatable PROTACs for precise protein degradation and cancer therapy.

Gao J, Yang L, Lei S, Zhou F, Nie H, Peng B, Xu T, Chen X, Yang X, Sheng C, Rao Y, Pu K, Jin J, Xu Z, Yu H. Gao J, et al. Among authors: sheng c. Sci Bull (Beijing). 2023 May 30;68(10):1069-1085. doi: 10.1016/j.scib.2023.04.028. Epub 2023 Apr 26. Sci Bull (Beijing). 2023. PMID: 37169612 Review.

5

Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer.

Cheng J, Li Y, Wang X, Dong G, Sheng C. Cheng J, et al. Among authors: sheng c. J Med Chem. 2020 Jul 23;63(14):7892-7905. doi: 10.1021/acs.jmedchem.0c00929. Epub 2020 Jul 14. J Med Chem. 2020. PMID: 32603594

6

Aptamer-PROTAC Conjugates (APCs) for Tumor-Specific Targeting in Breast Cancer.

He S, Gao F, Ma J, Ma H, Dong G, Sheng C. He S, et al. Among authors: sheng c. Angew Chem Int Ed Engl. 2021 Oct 18;60(43):23299-23305. doi: 10.1002/anie.202107347. Epub 2021 Aug 11. Angew Chem Int Ed Engl. 2021. PMID: 34240523

7

NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion.

Wu Y, Pu C, Fu Y, Dong G, Huang M, Sheng C. Wu Y, et al. Among authors: sheng c. Acta Pharm Sin B. 2022 Jun;12(6):2859-2868. doi: 10.1016/j.apsb.2021.12.017. Epub 2021 Dec 31. Acta Pharm Sin B. 2022. PMID: 35755293 Free PMC article.

8

Homobivalent, Trivalent, and Covalent PROTACs: Emerging Strategies for Protein Degradation.

Yan J, Li T, Miao Z, Wang P, Sheng C, Zhuang C. Yan J, et al. Among authors: sheng c. J Med Chem. 2022 Jul 14;65(13):8798-8827. doi: 10.1021/acs.jmedchem.2c00728. Epub 2022 Jun 28. J Med Chem. 2022. PMID: 35763424 Review.

9

Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer.

Bi K, Cheng J, He S, Fang Y, Huang M, Sheng C, Dong G. Bi K, et al. Among authors: sheng c. J Med Chem. 2023 Jan 12;66(1):1048-1062. doi: 10.1021/acs.jmedchem.2c01990. Epub 2022 Dec 23. J Med Chem. 2023. PMID: 36563407

10

PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders.

Chen S, Bi K, Liang H, Wu Z, Huang M, Chen X, Dong G, Sheng C. Chen S, et al. Among authors: sheng c. J Adv Res. 2024 Sep;63:219-230. doi: 10.1016/j.jare.2023.10.014. Epub 2023 Oct 31. J Adv Res. 2024. PMID: 37913903 Free PMC article.

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