Lescar J - Search Results

1

Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.

Wirjanata G, Lin J, Dziekan JM, El Sahili A, Chung Z, Tjia S, Binte Zulkifli NE, Boentoro J, Tham R, Jia LS, Go KD, Yu H, Partridge A, Olsen D, Prabhu N, Sobota RM, Nordlund P, Lescar J, Bozdech Z. Wirjanata G, et al. Among authors: lescar j. Cell Chem Biol. 2024 Apr 18;31(4):743-759.e8. doi: 10.1016/j.chembiol.2024.03.002. Epub 2024 Apr 8. Cell Chem Biol. 2024. PMID: 38593807

2

A Cascade Enzymatic Reaction Scheme for Irreversible Transpeptidative Protein Ligation.

Xia Y, Li F, Zhang X, Balamkundu S, Tang F, Hu S, Lescar J, Tam JP, Liu CF. Xia Y, et al. Among authors: lescar j. J Am Chem Soc. 2023 Mar 29;145(12):6838-6844. doi: 10.1021/jacs.2c13628. Epub 2023 Mar 16. J Am Chem Soc. 2023. PMID: 36924109

3

Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2.

Gu Y, Shunmuganathan B, Qian X, Gupta R, Tan RSW, Kozma M, Purushotorman K, Murali TM, Tan NYJ, Preiser PR, Lescar J, Nasir H, Somani J, Tambyah PA; SCOPE Cohort Study Group; Smith KGC, Renia L, Ng LFP, Lye DC, Young BE, MacAry PA. Gu Y, et al. Among authors: lescar j. Sci Rep. 2023 Dec 9;13(1):21810. doi: 10.1038/s41598-023-49231-w. Sci Rep. 2023. PMID: 38071323 Free PMC article.

4

The Phlebovirus Ribonucleoprotein: An Overview.

Ferron F, Lescar J. Ferron F, et al. Among authors: lescar j. Methods Mol Biol. 2024;2824:259-280. doi: 10.1007/978-1-0716-3926-9_17. Methods Mol Biol. 2024. PMID: 39039418 Review.

5

Substrate-binding glycine residues are major determinants for hydrolase and ligase activity of plant legumains.

Hemu X, Chan NY, Liew HT, Hu S, Zhang X, Serra A, Lescar J, Liu CF, Tam JP. Hemu X, et al. Among authors: lescar j. New Phytol. 2023 May;238(4):1534-1545. doi: 10.1111/nph.18841. Epub 2023 Mar 14. New Phytol. 2023. PMID: 36843268 Free article.

6

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Sep 16;14(1):21579. doi: 10.1038/s41598-024-70321-w. Sci Rep. 2024. PMID: 39284864 Free PMC article. No abstract available.

7

Inhibition of falcilysin from Plasmodium falciparum by interference with its closed-to-open dynamic transition.

Lin J, Yan X, Chung Z, Liew CW, El Sahili A, Pechnikova EV, Preiser PR, Bozdech Z, Gao YG, Lescar J. Lin J, et al. Among authors: lescar j. Commun Biol. 2024 Aug 31;7(1):1070. doi: 10.1038/s42003-024-06774-6. Commun Biol. 2024. PMID: 39217277 Free PMC article.

8

AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Apr 2;14(1):7526. doi: 10.1038/s41598-024-54655-z. Sci Rep. 2024. PMID: 38565852 Free PMC article.

9

Functional and Immunologic Mapping of Domains of the Reticulocyte-Binding Protein Plasmodium vivax PvRBP2a.

Tay MZ, Tang W, Lee WC, Ong ASM, Novera W, Malleret B, Carissimo G, Chacko AM, El-Sahili A, Lescar J, Fan Y, McGready RM, Chu CS, Chan JKY, Ng LFP, Russell B, Nosten F, Rénia L. Tay MZ, et al. Among authors: lescar j. J Infect Dis. 2024 Sep 23;230(3):e737-e742. doi: 10.1093/infdis/jiae111. J Infect Dis. 2024. PMID: 38441336 Free PMC article.

10

Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848.

Chung Z, Lin J, Wirjanata G, Dziekan JM, El Sahili A, Preiser PR, Bozdech Z, Lescar J. Chung Z, et al. Among authors: lescar j. J Biol Chem. 2024 Jan;300(1):105586. doi: 10.1016/j.jbc.2023.105586. Epub 2023 Dec 21. J Biol Chem. 2024. PMID: 38141766 Free PMC article.

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