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The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress.
Backes S, Bykov YS, Flohr T, Räschle M, Zhou J, Lenhard S, Krämer L, Mühlhaus T, Bibi C, Jann C, Smith JD, Steinmetz LM, Rapaport D, Storchová Z, Schuldiner M, Boos F, Herrmann JM. Backes S, et al. Among authors: lenhard s. Cell Rep. 2021 Apr 6;35(1):108936. doi: 10.1016/j.celrep.2021.108936. Cell Rep. 2021. PMID: 33826901 Free PMC article.
The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import.
Rödl S, den Brave F, Räschle M, Kizmaz B, Lenhard S, Groh C, Becker H, Zimmermann J, Morgan B, Richling E, Becker T, Herrmann JM. Rödl S, et al. Among authors: lenhard s. Life Sci Alliance. 2022 Oct 17;6(1):e202201526. doi: 10.26508/lsa.202201526. Print 2023 Jan. Life Sci Alliance. 2022. PMID: 36253107 Free PMC article.
The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
Lenhard S, Gerlich S, Khan A, Rödl S, Bökenkamp JE, Peker E, Zarges C, Faust J, Storchova Z, Räschle M, Riemer J, Herrmann JM. Lenhard S, et al. J Cell Biol. 2023 Oct 2;222(10):e202303002. doi: 10.1083/jcb.202303002. Epub 2023 Sep 8. J Cell Biol. 2023. PMID: 37682539 Free PMC article.
In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys.
Aweda TA, Cheng SH, Lenhard SC, Sepp A, Skedzielewski T, Hsu CY, Marshall S, Haag H, Kehler J, Jagdale P, Peter A, Schmid MA, Gehman A, Doan M, Mayer AP, Gorycki P, Fanget M, Colas C, Smith B, Maier CC, Alsaid H. Aweda TA, et al. Among authors: lenhard sc. Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):667-678. doi: 10.1007/s00259-022-06012-3. Epub 2022 Oct 28. Eur J Nucl Med Mol Imaging. 2023. PMID: 36305907 Free PMC article.
Multimodal imaging distribution assessment of a liposomal antibiotic in an infectious disease model.
Cheng SH, Groseclose MR, Mininger C, Bergstrom M, Zhang L, Lenhard SC, Skedzielewski T, Kelley ZD, Comroe D, Hong H, Cui H, Hoover JL, Rittenhouse S, Castellino S, Jucker BM, Alsaid H. Cheng SH, et al. Among authors: lenhard sc. J Control Release. 2022 Dec;352:199-210. doi: 10.1016/j.jconrel.2022.08.061. Epub 2022 Oct 20. J Control Release. 2022. PMID: 36084816 Free article.
In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice.
Lenhard SC, McAlexander A, Virtue A, Fieles W, Skedzielewski T, Rambo M, Trinh H, Cheng SH, Hong H, Isidro-Llobet A, Nadin A, Geske R, Klein JL, Lee D, Jucker BM, Hu E. Lenhard SC, et al. J Pharmacol Exp Ther. 2019 Sep;370(3):786-795. doi: 10.1124/jpet.119.257022. Epub 2019 Apr 1. J Pharmacol Exp Ther. 2019. PMID: 30936291
A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.
Karageorgis A, Lenhard SC, Yerby B, Forsgren MF, Liachenko S, Johansson E, Pilling MA, Peterson RA, Yang X, Williams DP, Ungersma SE, Morgan RE, Brouwer KLR, Jucker BM, Hockings PD. Karageorgis A, et al. Among authors: lenhard sc. PLoS One. 2018 May 17;13(5):e0197213. doi: 10.1371/journal.pone.0197213. eCollection 2018. PLoS One. 2018. PMID: 29771932 Free PMC article.
41 results