MacKenzie KR - Search Results

1

Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy.

Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B, Roy Chowdhury S, Korp JD, O'Malley BW, Lonard DM, Wang J. Lu D, et al. Among authors: mackenzie kr. J Med Chem. 2024 Apr 11;67(7):5333-5350. doi: 10.1021/acs.jmedchem.3c01596. Epub 2024 Mar 29. J Med Chem. 2024. PMID: 38551814 Free PMC article.

2

Quantitative real-time imaging of glutathione.

Jiang X, Chen J, Bajić A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletić-Savatić M, Wang J. Jiang X, et al. Among authors: mackenzie kr. Nat Commun. 2017 Jul 13;8:16087. doi: 10.1038/ncomms16087. Nat Commun. 2017. PMID: 28703127 Free PMC article.

3

Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria.

Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J. Chen J, et al. Among authors: mackenzie kr. ACS Sens. 2017 Sep 22;2(9):1257-1261. doi: 10.1021/acssensors.7b00425. Epub 2017 Aug 18. ACS Sens. 2017. PMID: 28809477 Free PMC article.

4

Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes†.

Li F, MacKenzie KR, Jain P, Santini C, Young DW, Matzuk MM. Li F, et al. Among authors: mackenzie kr. Biol Reprod. 2020 Aug 4;103(2):427-436. doi: 10.1093/biolre/ioaa043. Biol Reprod. 2020. PMID: 32285106 Free PMC article.

5

Metabolic profiling of norepinephrine reuptake inhibitor atomoxetine.

MacKenzie KR, Zhao M, Barzi M, Wang J, Bissig KD, Maletic-Savatic M, Jung SY, Li F. MacKenzie KR, et al. Eur J Pharm Sci. 2020 Oct 1;153:105488. doi: 10.1016/j.ejps.2020.105488. Epub 2020 Jul 23. Eur J Pharm Sci. 2020. PMID: 32712217 Free PMC article.

6

Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice.

Qin X, Hakenjos JM, MacKenzie KR, Barzi M, Chavan H, Nyshadham P, Wang J, Jung SY, Guner JZ, Chen S, Guo L, Krishnamurthy P, Bissig KD, Palmer S, Matzuk MM, Li F. Qin X, et al. Among authors: mackenzie kr. Drug Metab Dispos. 2022 Feb;50(2):128-139. doi: 10.1124/dmd.121.000633. Epub 2021 Nov 16. Drug Metab Dispos. 2022. PMID: 34785568 Free PMC article.

7

The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice.

Qin X, Xie C, Hakenjos JM, MacKenzie KR, Boyd SR, Barzi M, Bissig KD, Young DW, Li F. Qin X, et al. Among authors: mackenzie kr. Eur J Pharm Sci. 2023 Feb 1;181:106358. doi: 10.1016/j.ejps.2022.106358. Epub 2022 Dec 10. Eur J Pharm Sci. 2023. PMID: 36513193 Free PMC article.

8

Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC-MS-Based Metabolomic Approaches.

Qin X, Wang Y, MacKenzie KR, Hakenjos JM, Chen S, Khalil SM, Jung SY, Young DW, Guo L, Li F. Qin X, et al. Among authors: mackenzie kr. Chem Res Toxicol. 2023 Aug 21;36(8):1427-1438. doi: 10.1021/acs.chemrestox.3c00164. Epub 2023 Aug 2. Chem Res Toxicol. 2023. PMID: 37531179 Free PMC article.

9

CYP3A-Mediated Carbon-Carbon Bond Cleavages in Drug Metabolism.

Zhou J, Qin X, Zhou S, MacKenzie KR, Li F. Zhou J, et al. Among authors: mackenzie kr. Biomolecules. 2024 Sep 5;14(9):1125. doi: 10.3390/biom14091125. Biomolecules. 2024. PMID: 39334891 Free PMC article. Review.

10

Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.

Jimmidi R, Monsivais D, Ta HM, Sharma KL, Bohren KM, Chamakuri S, Liao Z, Li F, Hakenjos JM, Li JY, Mishina Y, Pan H, Qin X, Robers MB, Sankaran B, Tan Z, Tang S, Vasquez YM, Wilkinson J, Young DW, Palmer SS, MacKenzie KR, Kim C, Matzuk MM. Jimmidi R, et al. Among authors: mackenzie kr. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2413108121. doi: 10.1073/pnas.2413108121. Epub 2024 Nov 14. Proc Natl Acad Sci U S A. 2024. PMID: 39541346

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