Wenthe J - Search Results

1

LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study.

Musher BL, Rowinsky EK, Smaglo BG, Abidi W, Othman M, Patel K, Jawaid S, Jing J, Brisco A, Leen AM, Wu M, Sandin LC, Wenthe J, Eriksson E, Ullenhag GJ, Grilley B, Leja-Jarblad J, Hilsenbeck SG, Brenner MK, Loskog ASI. Musher BL, et al. Among authors: wenthe j. Lancet Oncol. 2024 Apr;25(4):488-500. doi: 10.1016/S1470-2045(24)00079-2. Lancet Oncol. 2024. PMID: 38547893 Clinical Trial.

2

CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling.

Naseri S, Cordova MM, Wenthe J, Lövgren T, Eriksson E, Loskog A, Ullenhag GJ. Naseri S, et al. Among authors: wenthe j. J Cell Mol Med. 2024 Apr;28(7):e18162. doi: 10.1111/jcmm.18162. J Cell Mol Med. 2024. PMID: 38494863 Free PMC article.

3

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models.

Wenthe J, Eriksson E, Hellström AC, Moreno R, Ullenhag G, Alemany R, Lövgren T, Loskog A. Wenthe J, et al. J Transl Med. 2023 Jul 27;21(1):506. doi: 10.1186/s12967-023-04374-2. J Transl Med. 2023. PMID: 37501121 Free PMC article.

4

Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition.

Wenthe J, Naseri S, Hellström AC, Moreno R, Ullenhag G, Alemany R, Lövgren T, Eriksson E, Loskog A. Wenthe J, et al. Mol Ther Oncolytics. 2022 Jan 10;24:429-442. doi: 10.1016/j.omto.2022.01.003. eCollection 2022 Mar 17. Mol Ther Oncolytics. 2022. PMID: 35141399 Free PMC article.

5

Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes.

Labani-Motlagh A, Naseri S, Wenthe J, Eriksson E, Loskog A. Labani-Motlagh A, et al. Among authors: wenthe j. Mol Ther Oncolytics. 2021 Feb 17;20:508-518. doi: 10.1016/j.omto.2021.02.007. eCollection 2021 Mar 26. Mol Ther Oncolytics. 2021. PMID: 33738337 Free PMC article.

6

Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy.

Wenthe J, Naseri S, Labani-Motlagh A, Enblad G, Wikström KI, Eriksson E, Loskog A, Lövgren T. Wenthe J, et al. Cancer Immunol Immunother. 2021 Oct;70(10):2851-2865. doi: 10.1007/s00262-021-02895-7. Epub 2021 Mar 5. Cancer Immunol Immunother. 2021. PMID: 33666760 Free PMC article.

7

Intratumoral immunostimulatory AdCD40L gene therapy in patients with advanced solid tumors.

Irenaeus S, Hellström V, Wenthe J, Krause J, Sundin A, Ahlström H, Tufveson G, Tötterman TH, Loskog A, Ullenhag GJ. Irenaeus S, et al. Among authors: wenthe j. Cancer Gene Ther. 2021 Nov;28(10-11):1188-1197. doi: 10.1038/s41417-020-00271-8. Epub 2020 Dec 14. Cancer Gene Ther. 2021. PMID: 33318679

8

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40.

Wenthe J, Naseri S, Hellström AC, Wiklund HJ, Eriksson E, Loskog A. Wenthe J, et al. Cancer Gene Ther. 2020 Dec;27(12):948-959. doi: 10.1038/s41417-020-0176-9. Epub 2020 May 1. Cancer Gene Ther. 2020. PMID: 32355275 Free PMC article.

9

IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-β, Collagen Type I, and PD-L1/PD-1.

Eriksson E, Milenova I, Wenthe J, Moreno R, Alemany R, Loskog A. Eriksson E, et al. Among authors: wenthe j. J Immunol. 2019 Feb 1;202(3):787-798. doi: 10.4049/jimmunol.1800717. Epub 2019 Jan 7. J Immunol. 2019. PMID: 30617223

10

A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia.

Enblad G, Karlsson H, Gammelgård G, Wenthe J, Lövgren T, Amini RM, Wikstrom KI, Essand M, Savoldo B, Hallböök H, Höglund M, Dotti G, Brenner MK, Hagberg H, Loskog A. Enblad G, et al. Among authors: wenthe j. Clin Cancer Res. 2018 Dec 15;24(24):6185-6194. doi: 10.1158/1078-0432.CCR-18-0426. Epub 2018 Aug 10. Clin Cancer Res. 2018. PMID: 30097433 Clinical Trial.

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