Ben-Sahra I - Search Results

1

Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.

Sahu U, Villa E, Reczek CR, Zhao Z, O'Hara BP, Torno MD, Mishra R, Shannon WD, Asara JM, Gao P, Shilatifard A, Chandel NS, Ben-Sahra I. Sahu U, et al. Among authors: ben sahra i. Science. 2024 Mar 29;383(6690):1484-1492. doi: 10.1126/science.adh2771. Epub 2024 Mar 28. Science. 2024. PMID: 38547260

2

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

Ben-Sahra I, Howell JJ, Asara JM, Manning BD. Ben-Sahra I, et al. Science. 2013 Mar 15;339(6125):1323-8. doi: 10.1126/science.1228792. Epub 2013 Feb 21. Science. 2013. PMID: 23429703 Free PMC article.

3

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.

Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM. Lall R, et al. Cell Death Differ. 2014 May;21(5):836-44. doi: 10.1038/cdd.2014.24. Epub 2014 Feb 28. Cell Death Differ. 2014. PMID: 24583639 Free PMC article.

4

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis.

Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. Liu XS, et al. Genes Dev. 2014 Sep 1;28(17):1917-28. doi: 10.1101/gad.245910.114. Genes Dev. 2014. PMID: 25184678 Free PMC article.

5

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD. Ben-Sahra I, et al. Science. 2016 Feb 12;351(6274):728-733. doi: 10.1126/science.aad0489. Science. 2016. PMID: 26912861 Free PMC article.

6

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.

Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, Henske EP. Lam HC, et al. Oncotarget. 2017 Aug 4;8(39):64714-64727. doi: 10.18632/oncotarget.19947. eCollection 2017 Sep 12. Oncotarget. 2017. PMID: 29029388 Free PMC article.

7

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD. Hoxhaj G, et al. Cell Rep. 2017 Oct 31;21(5):1331-1346. doi: 10.1016/j.celrep.2017.10.029. Cell Rep. 2017. PMID: 29091770 Free PMC article.

8

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.

Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB. Zhang S, et al. Cell Metab. 2019 Feb 5;29(2):443-456.e5. doi: 10.1016/j.cmet.2018.12.004. Epub 2018 Dec 27. Cell Metab. 2019. PMID: 30595481 Free PMC article.

9

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS.

Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM. Yuan M, et al. Nat Protoc. 2019 Feb;14(2):313-330. doi: 10.1038/s41596-018-0102-x. Nat Protoc. 2019. PMID: 30683937 Free PMC article.

10

Direct stimulation of NADP⁺ synthesis through Akt-mediated phosphorylation of NAD kinase.

Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Hoxhaj G, et al. Science. 2019 Mar 8;363(6431):1088-1092. doi: 10.1126/science.aau3903. Science. 2019. PMID: 30846598 Free PMC article.

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