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The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.
Balasubramanian A, Hsu AY, Ghimire L, Tahir M, Devant P, Fontana P, Du G, Liu X, Fabin D, Kambara H, Xie X, Liu F, Hasegawa T, Xu R, Yu H, Chen M, Kolakowski S, Trauger S, Larsen MR, Wei W, Wu H, Kagan JC, Lieberman J, Luo HR. Balasubramanian A, et al. Among authors: wu h. Sci Immunol. 2024 Apr 12;9(94):eadn1452. doi: 10.1126/sciimmunol.adn1452. Epub 2024 Apr 12. Sci Immunol. 2024. PMID: 38530158
Cryo-EM structure of the gasdermin A3 membrane pore.
Ruan J, Xia S, Liu X, Lieberman J, Wu H. Ruan J, et al. Among authors: wu h. Nature. 2018 May;557(7703):62-67. doi: 10.1038/s41586-018-0058-6. Epub 2018 Apr 25. Nature. 2018. PMID: 29695864 Free PMC article.
Monitoring gasdermin pore formation in vitro.
Xia S, Ruan J, Wu H. Xia S, et al. Among authors: wu h. Methods Enzymol. 2019;625:95-107. doi: 10.1016/bs.mie.2019.04.024. Epub 2019 May 23. Methods Enzymol. 2019. PMID: 31455540 Free PMC article.
Gasdermin D activity in inflammation and host defense.
Lieberman J, Wu H, Kagan JC. Lieberman J, et al. Among authors: wu h. Sci Immunol. 2019 Sep 6;4(39):eaav1447. doi: 10.1126/sciimmunol.aav1447. Sci Immunol. 2019. PMID: 31492708 Free PMC article. Review.
Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J. Zhang Z, et al. Among authors: wu h. Nature. 2020 Mar;579(7799):415-420. doi: 10.1038/s41586-020-2071-9. Epub 2020 Mar 11. Nature. 2020. PMID: 32188940 Free PMC article.
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. Hu JJ, et al. Among authors: wu h. Nat Immunol. 2020 Jul;21(7):736-745. doi: 10.1038/s41590-020-0669-6. Epub 2020 May 4. Nat Immunol. 2020. PMID: 32367036 Free PMC article.
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