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Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Membrez M, et al. Among authors: treebak jt. Nat Metab. 2024 Mar;6(3):433-447. doi: 10.1038/s42255-024-00997-x. Epub 2024 Mar 19. Nat Metab. 2024. PMID: 38504132 Free PMC article.
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging.
Snieckute G, Ryder L, Vind AC, Wu Z, Arendrup FS, Stoneley M, Chamois S, Martinez-Val A, Leleu M, Dreos R, Russell A, Gay DM, Genzor AV, Choi BS, Basse AL, Sass F, Dall M, Dollet LCM, Blasius M, Willis AE, Lund AH, Treebak JT, Olsen JV, Poulsen SS, Pownall ME, Jensen BAH, Clemmensen C, Gerhart-Hines Z, Gatfield D, Bekker-Jensen S. Snieckute G, et al. Among authors: treebak jt. Science. 2023 Dec 8;382(6675):eadf3208. doi: 10.1126/science.adf3208. Epub 2023 Dec 8. Science. 2023. PMID: 38060659
Seasonal light hours modulate peripheral clocks and energy metabolism in mice.
Small L, Lundell LS, Iversen J, Ehrlich AM, Dall M, Basse AL, Dalbram E, Hansen AN, Treebak JT, Barrès R, Zierath JR. Small L, et al. Among authors: treebak jt. Cell Metab. 2023 Oct 3;35(10):1722-1735.e5. doi: 10.1016/j.cmet.2023.08.005. Epub 2023 Sep 8. Cell Metab. 2023. PMID: 37689069 Free article.
PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity.
Backe MB, Andersen RC, Jensen M, Jin C, Hundahl C, Dmytriyeva O, Treebak JT, Hansen JB, Gerhart-Hines Z, Madsen KL, Holst B. Backe MB, et al. Among authors: treebak jt. J Endocr Soc. 2023 May 16;7(6):bvad057. doi: 10.1210/jendso/bvad057. eCollection 2023 May 5. J Endocr Soc. 2023. PMID: 37200849 Free PMC article.
Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans.
Peluso AA, Lundgaard AT, Babaei P, Mousovich-Neto F, Rocha AL, Damgaard MV, Bak EG, Gnanasekaran T, Dollerup OL, Trammell SAJ, Nielsen TS, Kern T, Abild CB, Sulek K, Ma T, Gerhart-Hines Z, Gillum MP, Arumugam M, Ørskov C, McCloskey D, Jessen N, Herrgård MJ, Mori MAS, Treebak JT. Peluso AA, et al. Among authors: treebak jt. NPJ Aging. 2023 Apr 3;9(1):7. doi: 10.1038/s41514-023-00106-4. NPJ Aging. 2023. PMID: 37012386 Free PMC article.
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