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RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation.
Fontaine V, Boumedine T, Monteiro E, Fournié M, Gersende G, Sahel JA, Picaud S, Veillet S, Lafont R, Latil M, Dilda PJ, Camelo S. Fontaine V, et al. Among authors: fournie m. Int J Mol Sci. 2024 Mar 6;25(5):3037. doi: 10.3390/ijms25053037. Int J Mol Sci. 2024. PMID: 38474284 Free PMC article.
Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.
Fontaine V, Monteiro E, Fournié M, Brazhnikova E, Boumedine T, Vidal C, Balducci C, Guibout L, Latil M, Dilda PJ, Veillet S, Sahel JA, Lafont R, Camelo S. Fontaine V, et al. Among authors: fournie m. Aging (Albany NY). 2020 Apr 7;12(7):6151-6171. doi: 10.18632/aging.103014. Epub 2020 Apr 7. Aging (Albany NY). 2020. PMID: 32255762 Free PMC article.
A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin.
Fontaine V, Fournié M, Monteiro E, Boumedine T, Balducci C, Guibout L, Latil M, Sahel JA, Veillet S, Dilda PJ, Lafont R, Camelo S. Fontaine V, et al. Among authors: fournie m. Aging (Albany NY). 2021 Sep 20;13(18):22040-22058. doi: 10.18632/aging.203558. Epub 2021 Sep 20. Aging (Albany NY). 2021. PMID: 34544906 Free PMC article.
Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD).
Fontaine V, Balducci C, Dinan L, Monteiro E, Boumedine T, Fournié M, Nguyen V, Guibout L, Clatot J, Latil M, Veillet S, Sahel JA, Lafont R, Dilda PJ, Camelo S. Fontaine V, et al. Among authors: fournie m. Int J Mol Sci. 2023 Mar 10;24(6):5296. doi: 10.3390/ijms24065296. Int J Mol Sci. 2023. PMID: 36982372 Free PMC article.
National Survey of Indigenous primary healthcare capacity and delivery models in Canada: the TransFORmation of IndiGEnous PrimAry HEAlthcare delivery (FORGE AHEAD) community profile survey.
Tompkins JW, Mequanint S, Barre DE, Fournie M, Green ME, Hanley AJ, Hayward MN, Zwarenstein M, Harris SB; FORGE AHEAD Program Team. Tompkins JW, et al. Among authors: fournie m. BMC Health Serv Res. 2018 Nov 1;18(1):828. doi: 10.1186/s12913-018-3578-8. BMC Health Serv Res. 2018. PMID: 30382912 Free PMC article.
28 results