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Metformin reduces the clonal fitness of Dnmt3aR878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.
Hosseini M, Voisin V, Chegini A, Varesi A, Cathelin S, Ayyathan DM, Liu ACH, Yang Y, Wang V, Maher A, Grignano E, Reisz JA, D'Alessandro A, Young K, Wu Y, Fiumara M, Ferrari S, Naldini L, Gaiti F, Pai S, Schimmer AD, Bader GD, Dick JE, Xie SZ, Trowbridge JJ, Chan SM. Hosseini M, et al. Res Sq [Preprint]. 2024 Feb 6:rs.3.rs-3874821. doi: 10.21203/rs.3.rs-3874821/v1. Res Sq. 2024. PMID: 38405837 Free PMC article. Preprint.
Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro.
Nemkov T, Key A, Stephenson D, Earley EJ, Keele GR, Hay A, Amireault P, Casimir M, Dussiot M, Dzieciatkowska M, Reisz JA, Deng X, Stone M, Kleinman S, Spitalnik SL, Hansen KC, Norris PJ, Churchill GA, Busch MP, Roubinian N, Page GP, Zimring JC, Arduini A, D'Alessandro A. Nemkov T, et al. Blood. 2024 Jun 13;143(24):2517-2533. doi: 10.1182/blood.2024023983. Blood. 2024. PMID: 38513237
Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice.
Baker PR 2nd, Li AS, Griffin BR, Gil HW, Orlicky DJ, Fox BM, Park B, Sparagna GC, Goff J, Altmann C, Elajaili H, Okamura K, He Z, Stephenson D, D'Alessandro A, Reisz JA, Nozik ES, Sucharov CC, Faubel S. Baker PR 2nd, et al. Sci Rep. 2024 Jun 15;14(1):13862. doi: 10.1038/s41598-024-64586-4. Sci Rep. 2024. PMID: 38879688 Free PMC article.
Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes.
Nemkov T, Stephenson D, Earley EJ, Keele GR, Hay A, Key A, Haiman ZB, Erickson C, Dzieciatkowska M, Reisz JA, Moore A, Stone M, Deng X, Kleinman S, Spitalnik SL, Hod EA, Hudson KE, Hansen KC, Palsson BO, Churchill GA, Roubinian N, Norris PJ, Busch MP, Zimring JC, Page GP, D'Alessandro A. Nemkov T, et al. Cell Metab. 2024 Sep 3;36(9):1979-1997.e13. doi: 10.1016/j.cmet.2024.06.007. Epub 2024 Jul 3. Cell Metab. 2024. PMID: 38964323
Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity.
Kuo LW, Crump LS, O'Neill K, Williams MM, Christenson JL, Spoelstra NS, Roy MK, Argabright A, Reisz JA, D'Alessandro A, Boorgula MP, Goodspeed A, Bickerdike M, Bitler BG, Richer JK. Kuo LW, et al. Cancer Res Commun. 2024 Oct 1;4(10):2699-2713. doi: 10.1158/2767-9764.CRC-24-0272. Cancer Res Commun. 2024. PMID: 39311710 Free PMC article.
Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Rondeau V, Berman JM, Ling T, O'Brien C, Culp-Hill R, Reisz JA, Wunderlich M, Chueh Y, Jiménez-Camacho KE, Sexton C, Carter KM, Stillwell C, St-Germain J, Yendi D, Gupta A, Shi M, Bourdine A, Paralkar VR, Jahangiri S, Hope KJ, Tikhonova AN, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. Rondeau V, et al. Sci Transl Med. 2024 Sep 25;16(766):eadn1285. doi: 10.1126/scitranslmed.adn1285. Epub 2024 Sep 25. Sci Transl Med. 2024. PMID: 39321266
Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism.
Lee SCS, Pyo AHA, Mohammadi H, Zhang J, Dvorkin-Gheva A, Malbeteau L, Chung S, Khan S, Ciudad MT, Rondeau V, Cairns RA, Kislinger T, McGaha TL, Wouters BG, Reisz JA, Culp-Hill R, D'Alessandro A, Jones CL, Koritzinsky M. Lee SCS, et al. Sci Adv. 2024 Oct 4;10(40):eadq0355. doi: 10.1126/sciadv.adq0355. Epub 2024 Oct 2. Sci Adv. 2024. PMID: 39356760 Free PMC article.
1,335 results