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BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking.
Tran S, Juliani J, Harris TJ, Evangelista M, Ratcliffe J, Ellis SL, Baloyan D, Reehorst CM, Nightingale R, Luk IY, Jenkins LJ, Ghilas S, Yakou MH, Inguanti C, Johnson C, Buchert M, Lee JC, De Cruz P, Duszyc K, Gleeson PA, Kile BT, Mielke LA, Yap AS, Mariadason JM, Fairlie WD, Lee EF. Tran S, et al. Among authors: harris tj. Commun Biol. 2024 Feb 20;7(1):209. doi: 10.1038/s42003-024-05890-7. Commun Biol. 2024. PMID: 38378743 Free PMC article.
Diversity in the intrinsic apoptosis pathway of nematodes.
Young ND, Harris TJ, Evangelista M, Tran S, Wouters MA, Soares da Costa TP, Kershaw NJ, Gasser RB, Smith BJ, Lee EF, Fairlie WD. Young ND, et al. Among authors: harris tj. Commun Biol. 2020 Aug 28;3(1):478. doi: 10.1038/s42003-020-01208-5. Commun Biol. 2020. PMID: 32859965 Free PMC article.
Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Lee EF, Smith NA, Soares da Costa TP, Meftahi N, Yao S, Harris TJ, Tran S, Pettikiriarachchi A, Perugini MA, Keizer DW, Evangelista M, Smith BJ, Fairlie WD. Lee EF, et al. Among authors: harris tj. Autophagy. 2019 May;15(5):785-795. doi: 10.1080/15548627.2018.1564557. Epub 2019 Jan 9. Autophagy. 2019. PMID: 30626284 Free PMC article.
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival.
Lee EF, Harris TJ, Tran S, Evangelista M, Arulananda S, John T, Ramnac C, Hobbs C, Zhu H, Gunasingh G, Segal D, Behren A, Cebon J, Dobrovic A, Mariadason JM, Strasser A, Rohrbeck L, Haass NK, Herold MJ, Fairlie WD. Lee EF, et al. Among authors: harris tj. Cell Death Dis. 2019 Apr 24;10(5):342. doi: 10.1038/s41419-019-1568-3. Cell Death Dis. 2019. PMID: 31019203 Free PMC article.
BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.
Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, Lee EF, John T, Fairlie WD. Arulananda S, et al. Among authors: harris tj. Cell Death Discov. 2020 Oct 31;6(1):114. doi: 10.1038/s41420-020-00348-1. Cell Death Discov. 2020. PMID: 33298868 Free PMC article.
Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.
Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, Lee EF, John T, Fairlie WD. Arulananda S, et al. Among authors: harris tj. Cell Death Discov. 2021 Jun 15;7(1):146. doi: 10.1038/s41420-020-00388-7. Cell Death Discov. 2021. PMID: 34131107 Free PMC article. No abstract available.
Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Nguyen W, Lee EF, Evangelista M, Lee M, Harris TJ, Colman PM, Smith NA, Williams LB, Jarman KE, Lowes KN, Haeberli C, Keiser J, Smith BJ, Fairlie WD, Sleebs BE. Nguyen W, et al. Among authors: harris tj. ACS Infect Dis. 2021 May 14;7(5):1143-1163. doi: 10.1021/acsinfecdis.0c00700. Epub 2021 Feb 1. ACS Infect Dis. 2021. PMID: 33523649
223 results