Kirabo A - Search Results

1

LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation.

Murphy MB, Yang Z, Subati T, Farber-Eger E, Kim K, Blackwell DJ, Fleming MR, Stark JM, Van Amburg JC, Woodall KK, Van Beusecum JP, Agrawal V, Smart CD, Pitzer A, Atkinson JB, Fogo AB, Bastarache JA, Kirabo A, Wells QS, Madhur MS, Barnett JV, Murray KT. Murphy MB, et al. Among authors: kirabo a. Cardiovasc Res. 2024 Jul 2;120(8):899-913. doi: 10.1093/cvr/cvae036. Cardiovasc Res. 2024. PMID: 38377486

2

Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments.

Majumder A, Kirabo A, Karrupiah K, Tsuda S, Caldwell-Busby J, Cardounel AJ, Keseru GM, Sayeski PP. Majumder A, et al. Among authors: kirabo a. Biochemistry. 2011 Sep 13;50(36):7774-86. doi: 10.1021/bi200847n. Epub 2011 Aug 17. Biochemistry. 2011. PMID: 21823612 Free PMC article.

3

A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth.

Majumder A, Magis AT, Park SO, Figueroa NC, Baskin R, Kirabo A, Allan RW, Zhao ZJ, Bisht KS, Keseru GM, Sayeski PP. Majumder A, et al. Among authors: kirabo a. Exp Hematol. 2012 Jan;40(1):22-34. doi: 10.1016/j.exphem.2011.10.003. Epub 2011 Oct 20. Exp Hematol. 2012. PMID: 22019628 Free PMC article.

4

Elevated levels of mast cells are involved in pruritus associated with polycythemia vera in JAK2V617F transgenic mice.

Jin X, Zhao W, Kirabo A, Park SO, Ho WT, Sayeski PP, Zhao ZJ. Jin X, et al. Among authors: kirabo a. J Immunol. 2014 Jul 15;193(2):477-84. doi: 10.4049/jimmunol.1301946. Epub 2014 Jun 11. J Immunol. 2014. PMID: 24920845

5

The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.

Kirabo A, Park SO, Majumder A, Gali M, Reinhard MK, Wamsley HL, Zhao ZJ, Cogle CR, Bisht KS, Keserü GM, Sayeski PP. Kirabo A, et al. Neoplasia. 2011 Nov;13(11):1058-68. doi: 10.1593/neo.111112. Neoplasia. 2011. PMID: 22131881 Free PMC article.

6

Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.

Kiss R, Polgár T, Kirabo A, Sayyah J, Figueroa NC, List AF, Sokol L, Zuckerman KS, Gali M, Bisht KS, Sayeski PP, Keseru GM. Kiss R, et al. Among authors: kirabo a. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3598-601. doi: 10.1016/j.bmcl.2009.04.138. Epub 2009 May 5. Bioorg Med Chem Lett. 2009. PMID: 19447617 Free PMC article.

7

Arterial stiffness in adults with Long COVID in sub-Saharan Africa.

Theresa C, Katebe B, Shibao CA, Kirabo A. Theresa C, et al. Among authors: kirabo a. Physiol Rep. 2024 Sep;12(17):e70029. doi: 10.14814/phy2.70029. Physiol Rep. 2024. PMID: 39251404 Free PMC article.

8

Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation.

McDoom I, Ma X, Kirabo A, Lee KY, Ostrov DA, Sayeski PP. McDoom I, et al. Among authors: kirabo a. Biochemistry. 2008 Aug 12;47(32):8326-34. doi: 10.1021/bi800867d. Epub 2008 Jul 18. Biochemistry. 2008. PMID: 18636744 Free PMC article.

9

Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.

Kirabo A, Oh SP, Kasahara H, Wagner KU, Sayeski PP. Kirabo A, et al. J Mol Cell Cardiol. 2011 Jun;50(6):1026-34. doi: 10.1016/j.yjmcc.2011.03.005. Epub 2011 Mar 17. J Mol Cell Cardiol. 2011. PMID: 21420414 Free PMC article.

10

The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.

Kirabo A, Park SO, Wamsley HL, Gali M, Baskin R, Reinhard MK, Zhao ZJ, Bisht KS, Keserű GM, Cogle CR, Sayeski PP. Kirabo A, et al. Am J Pathol. 2012 Sep;181(3):858-65. doi: 10.1016/j.ajpath.2012.05.033. Epub 2012 Jul 13. Am J Pathol. 2012. PMID: 22796437 Free PMC article.

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