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Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer.
Li Y, Chang RB, Stone ML, Delman D, Markowitz K, Xue Y, Coho H, Herrera VM, Li JH, Zhang L, Choi-Bose S, Giannone M, Shin SM, Coyne EM, Hernandez A, Gross NE, Charmsaz S, Ho WJ, Lee JW, Beatty GL. Li Y, et al. Among authors: coyne em. Cell Rep Med. 2024 Feb 20;5(2):101397. doi: 10.1016/j.xcrm.2024.101397. Epub 2024 Feb 1. Cell Rep Med. 2024. PMID: 38307029 Free PMC article.
Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade.
Shu DH, Ho WJ, Kagohara LT, Girgis A, Shin SM, Danilova L, Lee JW, Sidiropoulos DN, Mitchell S, Munjal K, Howe K, Bendinelli KJ, Qi H, Mo G, Montagne J, Leatherman JM, Lopez-Vidal TY, Zhu Q, Huff AL, Yuan X, Hernandez A, Coyne EM, Zaidi N, Zabransky DJ, Engle LL, Ogurtsova A, Baretti M, Laheru D, Durham JN, Wang H, Anders R, Jaffee EM, Fertig EJ, Yarchoan M. Shu DH, et al. Among authors: coyne em. bioRxiv [Preprint]. 2023 Oct 26:2023.10.16.562104. doi: 10.1101/2023.10.16.562104. bioRxiv. 2023. PMID: 37904980 Free PMC article. Preprint.
Preventing NK cell activation in the damaged liver induced by cabozantinib/PD-1 blockade increases survival in hepatocellular carcinoma models.
Morita S, Kikuchi H, Birch G, Matsui A, Morita A, Kobayashi T, Ruan Z, Huang P, Hernandez A, Coyne EM, Shin SM, Yarchoan M, Mino-Kenudson M, Romee R, Ho WJ, Duda DG. Morita S, et al. Among authors: coyne em. bioRxiv [Preprint]. 2023 Oct 23:2023.10.20.563378. doi: 10.1101/2023.10.20.563378. bioRxiv. 2023. PMID: 37961529 Free PMC article. Preprint.
Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma.
Gross NE, Zhang Z, Mitchell JT, Charmsaz S, Hernandez AG, Coyne EM, Shin SM, Vargas Carvajal DC, Sidiropoulos DN, Cho Y, Mo G, Yuan X, Cannon C, Suresh Babu J, Lyman MR, Armstrong T, Kagohara LT, Bever KM, Le DT, Jaffee EM, Fertig EJ, Ho WJ. Gross NE, et al. Among authors: coyne em. JCI Insight. 2024 Aug 6:e179292. doi: 10.1172/jci.insight.179292. Online ahead of print. JCI Insight. 2024. PMID: 39106104 Free article.
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration.
Bell ATF, Mitchell JT, Kiemen AL, Lyman M, Fujikura K, Lee JW, Coyne E, Shin SM, Nagaraj S, Deshpande A, Wu PH, Sidiropoulos DN, Erbe R, Stern J, Chan R, Williams S, Chell JM, Ciotti L, Zimmerman JW, Wirtz D, Ho WJ, Zaidi N, Thompson E, Jaffee EM, Wood LD, Fertig EJ, Kagohara LT. Bell ATF, et al. Among authors: coyne e. Cell Syst. 2024 Aug 21;15(8):753-769.e5. doi: 10.1016/j.cels.2024.07.001. Epub 2024 Aug 7. Cell Syst. 2024. PMID: 39116880