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Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models.
Jiao Y, Yan J, Sutaria DS, Lu P, Vicchiarelli M, Reyna Z, Ruiz-Delgado J, Burk E, Moon E, Shah NR, Spellberg B, Bonomo RA, Drusano GL, Louie A, Luna BM, Bulitta JB. Jiao Y, et al. Among authors: spellberg b. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0139423. doi: 10.1128/aac.01394-23. Epub 2024 Jan 30. Antimicrob Agents Chemother. 2024. PMID: 38289076 Free PMC article.
Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice.
Jiao Y, Yan J, Vicchiarelli M, Sutaria DS, Lu P, Reyna Z, Spellberg B, Bonomo RA, Drusano GL, Louie A, Luna BM, Bulitta JB. Jiao Y, et al. Among authors: spellberg b. Antimicrob Agents Chemother. 2023 May 17;67(5):e0019723. doi: 10.1128/aac.00197-23. Epub 2023 Apr 6. Antimicrob Agents Chemother. 2023. PMID: 37022153 Free PMC article.
Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates.
Lu P, Alletto F, Lee B, Burk E, Martinez J, Prati F, Caselli E, Spellberg B, Luna B. Lu P, et al. Among authors: spellberg b. PLoS One. 2023 Jun 13;18(6):e0287102. doi: 10.1371/journal.pone.0287102. eCollection 2023. PLoS One. 2023. PMID: 37310985 Free PMC article.
Correction: 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases.
Rossi MA, Martinez V, Hinchliffe P, Mojica MF, Castillo V, Moreno DM, Smith R, Spellberg B, Drusano GL, Banchio C, Bonomo RA, Spencer J, Vila AJ, Mahler G. Rossi MA, et al. Among authors: spellberg b. Chem Sci. 2023 Aug 15;14(34):9226. doi: 10.1039/d3sc90150e. eCollection 2023 Aug 30. Chem Sci. 2023. PMID: 37655038 Free PMC article.
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens.
Yan J, Nielsen TB, Lu P, Talyansky Y, Slarve M, Reza H, Novakovic B, Netea MG, Keller AE, Warren T, DiGiandomenico A, Sellman BR, Luna BM, Spellberg B. Yan J, et al. Among authors: spellberg b. Sci Transl Med. 2023 Oct 4;15(716):eadf9556. doi: 10.1126/scitranslmed.adf9556. Epub 2023 Oct 4. Sci Transl Med. 2023. PMID: 37792959 Free PMC article.
Polymyxins retain in vitro activity and in vivo efficacy against "resistant" Acinetobacter baumannii strains when tested in physiological conditions.
Rubio J, Yan J, Miller S, Cheng J, Li R, Builta Z, Aoyagi K, Fisher M, She R, Spellberg B, Luna B. Rubio J, et al. Among authors: spellberg b. Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0072524. doi: 10.1128/aac.00725-24. Epub 2024 Sep 6. Antimicrob Agents Chemother. 2024. PMID: 39240097 Free PMC article.
277 results