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EXO1 protects BRCA1-deficient cells against toxic DNA lesions.
van de Kooij B, Schreuder A, Pavani R, Garzero V, Uruci S, Wendel TJ, van Hoeck A, San Martin Alonso M, Everts M, Koerse D, Callen E, Boom J, Mei H, Cuppen E, Luijsterburg MS, van Vugt MATM, Nussenzweig A, van Attikum H, Noordermeer SM. van de Kooij B, et al. Among authors: van vugt matm. Mol Cell. 2024 Feb 15;84(4):659-674.e7. doi: 10.1016/j.molcel.2023.12.039. Epub 2024 Jan 23. Mol Cell. 2024. PMID: 38266640 Free article.
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Gogola E, Duarte AA, de Ruiter JR, Wiegant WW, Schmid JA, de Bruijn R, James DI, Guerrero Llobet S, Vis DJ, Annunziato S, van den Broek B, Barazas M, Kersbergen A, van de Ven M, Tarsounas M, Ogilvie DJ, van Vugt M, Wessels LFA, Bartkova J, Gromova I, Andújar-Sánchez M, Bartek J, Lopes M, van Attikum H, Borst P, Jonkers J, Rottenberg S. Gogola E, et al. Cancer Cell. 2018 Jun 11;33(6):1078-1093.e12. doi: 10.1016/j.ccell.2018.05.008. Cancer Cell. 2018. PMID: 29894693 Free article.
Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer.
Guerrero Llobet S, van der Vegt B, Jongeneel E, Bense RD, Zwager MC, Schröder CP, Everts M, Fehrmann RSN, de Bock GH, van Vugt MATM. Guerrero Llobet S, et al. Among authors: van vugt matm, van der vegt b. NPJ Breast Cancer. 2020 Sep 7;6:40. doi: 10.1038/s41523-020-00181-w. eCollection 2020. NPJ Breast Cancer. 2020. PMID: 32964114 Free PMC article.
An mRNA expression-based signature for oncogene-induced replication-stress.
Guerrero Llobet S, Bhattacharya A, Everts M, Kok K, van der Vegt B, Fehrmann RSN, van Vugt MATM. Guerrero Llobet S, et al. Among authors: van vugt matm, van der vegt b. Oncogene. 2022 Feb;41(8):1216-1224. doi: 10.1038/s41388-021-02162-0. Epub 2022 Jan 29. Oncogene. 2022. PMID: 35091678 Free PMC article.
Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51.
Heijink AM, Stok C, Porubsky D, Manolika EM, de Kanter JK, Kok YP, Everts M, de Boer HR, Audrey A, Bakker FJ, Wierenga E, Tijsterman M, Guryev V, Spierings DCJ, Knipscheer P, van Boxtel R, Ray Chaudhuri A, Lansdorp PM, van Vugt MATM. Heijink AM, et al. Among authors: van vugt matm, van boxtel r. Nat Commun. 2022 Nov 7;13(1):6722. doi: 10.1038/s41467-022-34519-8. Nat Commun. 2022. PMID: 36344511 Free PMC article.
FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics.
Stok C, Tsaridou S, van den Tempel N, Everts M, Wierenga E, Bakker FJ, Kok Y, Alves IT, Jae LT, Raas MWD, Huis In 't Veld PJ, de Boer HR, Bhattacharya A, Karanika E, Warner H, Chen M, van de Kooij B, Dessapt J, Ter Morsche L, Perepelkina P, Fradet-Turcotte A, Guryev V, Tromer EC, Chan KL, Fehrmann RSN, van Vugt MATM. Stok C, et al. Among authors: van vugt matm. Cell Rep. 2023 Jul 25;42(7):112668. doi: 10.1016/j.celrep.2023.112668. Epub 2023 Jun 21. Cell Rep. 2023. PMID: 37347663 Free article.
The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks.
van de Kooij B, van der Wal FJ, Rother MB, Creixell P, Stout M, Wiegant W, Joughin BA, Vornberger J, van Vugt MATM, Altmeyer M, Yaffe MB, van Attikum H. van de Kooij B, et al. Among authors: van vugt matm. bioRxiv [Preprint]. 2023 Sep 6:2023.09.05.556391. doi: 10.1101/2023.09.05.556391. bioRxiv. 2023. Update in: Nat Commun. 2024 Aug 16;15(1):7076. doi: 10.1038/s41467-024-51090-6 PMID: 37732274 Free PMC article. Updated. Preprint.
105 results