Coombs JR - Search Results

1

NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.

Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K. Coombs JR, et al. Sci Signal. 2024 Jan 23;17(820):eabg8145. doi: 10.1126/scisignal.abg8145. Epub 2024 Jan 23. Sci Signal. 2024. PMID: 38261657

2

The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis.

Holley CL, Emming S, Monteleone MM, Mellacheruvu M, Kenney KM, Lawrence GMEP, Coombs JR, Burgener SS, Schroder K. Holley CL, et al. Among authors: coombs jr. Cell Chem Biol. 2024 May 16;31(5):962-972.e4. doi: 10.1016/j.chembiol.2024.04.012. Cell Chem Biol. 2024. PMID: 38759620

3

Radical Perfluoroalkylation of Arenes via Carbanion Intermediates.

Hernandez LW, Gallagher WP, Guerrero CA, Gonzalez-Bobes F, Coombs JR. Hernandez LW, et al. Among authors: coombs jr. J Org Chem. 2021 Aug 6;86(15):10903-10913. doi: 10.1021/acs.joc.1c01296. Epub 2021 Jul 21. J Org Chem. 2021. PMID: 34286987

4

Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores.

McDaniel J, Farley CA, Ramirez A, Sandhu B, Sarjeant A, Shi Q, Han A, Gallagher WP, Hynes J Jr, Dhar TGM, Gonzalez-Bobes F, Coombs JR, Marcoux D. McDaniel J, et al. Among authors: coombs jr. Org Lett. 2021 Jan 1;23(1):60-65. doi: 10.1021/acs.orglett.0c03695. Epub 2020 Dec 22. Org Lett. 2021. PMID: 33351641

5

One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent.

Shi Q, Greenwood NS, Meehan MC, Park H, Galella M, Sandhu B, Khandelwal P, Coombs JR, Gallagher WP, Guerrero CA, Hynes J Jr, Dhar TGM, Gonzalez Bobes F, Marcoux D. Shi Q, et al. Among authors: coombs jr. Org Lett. 2019 Nov 15;21(22):9198-9202. doi: 10.1021/acs.orglett.9b03560. Epub 2019 Oct 24. Org Lett. 2019. PMID: 31647672

6

Palladium(0)-Catalyzed Directed syn-1,2-Carboboration and -Silylation: Alkene Scope, Applications in Dearomatization, and Stereocontrol by a Chiral Auxiliary.

Liu Z, Chen J, Lu HX, Li X, Gao Y, Coombs JR, Goldfogel MJ, Engle KM. Liu Z, et al. Among authors: coombs jr. Angew Chem Int Ed Engl. 2019 Nov 18;58(47):17068-17073. doi: 10.1002/anie.201910304. Epub 2019 Oct 8. Angew Chem Int Ed Engl. 2019. PMID: 31538388 Free PMC article.

7

Enantioselective Synthesis of Nonracemic Geminal Silylboronates by Pt-Catalyzed Hydrosilylation.

Szymaniak AA, Zhang C, Coombs JR, Morken JP. Szymaniak AA, et al. Among authors: coombs jr. ACS Catal. 2018 Apr 6;8(4):2897-2901. doi: 10.1021/acscatal.8b00221. Epub 2018 Feb 23. ACS Catal. 2018. PMID: 31485379 Free PMC article.

8

Improving Robustness: In Situ Generation of a Pd(0) Catalyst for the Cyanation of Aryl Bromides.

Coombs JR, Fraunhoffer KJ, Simmons EM, Stevens JM, Wisniewski SR, Yu M. Coombs JR, et al. J Org Chem. 2017 Jul 7;82(13):7040-7044. doi: 10.1021/acs.joc.7b01003. Epub 2017 Jun 22. J Org Chem. 2017. PMID: 28594174

9

Catalytic Enantioselective Functionalization of Unactivated Terminal Alkenes.

Coombs JR, Morken JP. Coombs JR, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2636-49. doi: 10.1002/anie.201507151. Epub 2016 Jan 13. Angew Chem Int Ed Engl. 2016. PMID: 26764019 Free PMC article. Review.

10

Synthesis of vinyl boronates from aldehydes by a practical boron-Wittig reaction.

Coombs JR, Zhang L, Morken JP. Coombs JR, et al. Org Lett. 2015 Apr 3;17(7):1708-11. doi: 10.1021/acs.orglett.5b00480. Epub 2015 Mar 23. Org Lett. 2015. PMID: 25799147 Free PMC article.

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