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Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia.
Huang AY, Zhou Z, Talukdar M, Miller MB, Chhouk B, Enyenihi L, Rosen I, Stronge E, Zhao B, Kim D, Choi J, Khoshkhoo S, Kim J, Ganz J, Travaglini K, Gabitto M, Hodge R, Kaplan E, Lein E, De Jager PL, Bennett DA, Lee EA, Walsh CA. Huang AY, et al. Among authors: kim d, kim j. bioRxiv [Preprint]. 2024 Jan 4:2024.01.03.574078. doi: 10.1101/2024.01.03.574078. bioRxiv. 2024. PMID: 38260600 Free PMC article. Preprint.
APP gene copy number changes reflect exogenous contamination.
Kim J, Zhao B, Huang AY, Miller MB, Lodato MA, Walsh CA, Lee EA. Kim J, et al. Nature. 2020 Aug;584(7821):E20-E28. doi: 10.1038/s41586-020-2522-3. Epub 2020 Aug 19. Nature. 2020. PMID: 32814883 Free PMC article. No abstract available.
Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain.
Ganz J, Maury EA, Becerra B, Bizzotto S, Doan RN, Kenny CJ, Shin T, Kim J, Zhou Z, Ligon KL, Lee EA, Walsh CA. Ganz J, et al. Among authors: kim j. Cancer Discov. 2022 Jan;12(1):172-185. doi: 10.1158/2159-8290.CD-21-0245. Epub 2021 Aug 13. Cancer Discov. 2022. PMID: 34389641 Free PMC article.
Somatic genomic changes in single Alzheimer's disease neurons.
Miller MB, Huang AY, Kim J, Zhou Z, Kirkham SL, Maury EA, Ziegenfuss JS, Reed HC, Neil JE, Rento L, Ryu SC, Ma CC, Luquette LJ, Ames HM, Oakley DH, Frosch MP, Hyman BT, Lodato MA, Lee EA, Walsh CA. Miller MB, et al. Among authors: kim j. Nature. 2022 Apr;604(7907):714-722. doi: 10.1038/s41586-022-04640-1. Epub 2022 Apr 20. Nature. 2022. PMID: 35444284 Free PMC article.
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements.
Luquette LJ, Miller MB, Zhou Z, Bohrson CL, Zhao Y, Jin H, Gulhan D, Ganz J, Bizzotto S, Kirkham S, Hochepied T, Libert C, Galor A, Kim J, Lodato MA, Garaycoechea JI, Gawad C, West J, Walsh CA, Park PJ. Luquette LJ, et al. Among authors: kim j. Nat Genet. 2022 Oct;54(10):1564-1571. doi: 10.1038/s41588-022-01180-2. Epub 2022 Sep 26. Nat Genet. 2022. PMID: 36163278 Free PMC article.
Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations.
Zhou Z, Kim J, Huang AY, Nolan M, Park J, Doan R, Shin T, Miller MB, Chhouk B, Morillo K, Yeh RC, Kenny C, Neil JE, Lee CZ, Ohkubo T, Ravits J, Ansorge O, Ostrow LW, Lagier-Tourenne C, Lee EA, Walsh CA. Zhou Z, et al. Among authors: kim j. bioRxiv [Preprint]. 2023 Dec 1:2023.11.30.569436. doi: 10.1101/2023.11.30.569436. bioRxiv. 2023. PMID: 38077003 Free PMC article. Preprint.
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