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Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability.
Roth JR, Rush T, Thompson SJ, Aldaher AR, Dunn TB, Mesina JS, Cochran JN, Boyle NR, Dean HB, Yang Z, Pathak V, Ruiz P, Wu M, Day JJ, Bostwick JR, Suto MJ, Augelli-Szafran CE, Roberson ED. Roth JR, et al. Among authors: dean hb. Neurotherapeutics. 2024 Jan;21(1):e00291. doi: 10.1016/j.neurot.2023.10.001. Epub 2023 Dec 19. Neurotherapeutics. 2024. PMID: 38241154 Free PMC article.
Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42.
Kober DL, Stuchell-Brereton MD, Kluender CE, Dean HB, Strickland MR, Steinberg DF, Nelson SS, Baban B, Holtzman DM, Frieden C, Alexander-Brett J, Roberson ED, Song Y, Brett TJ. Kober DL, et al. Among authors: dean hb. Alzheimers Dement. 2020 Oct 8:10.1002/alz.12194. doi: 10.1002/alz.12194. Online ahead of print. Alzheimers Dement. 2020. PMID: 33090700 Free PMC article.