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Page 1
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nishiguchi G, Mascibroda LG, Young SM, Caine EA, Abdelhamed S, Kooijman JJ, Miller DJ, Das S, McGowan K, Mayasundari A, Shi Z, Barajas JM, Hiltenbrand R, Aggarwal A, Chang Y, Mishra V, Narina S, Thomas M, Loughran AJ, Kalathur R, Yu K, Zhou S, Wang X, High AA, Peng J, Pruett-Miller SM, Daniels DL, Urh M, Shelat AA, Mullighan CG, Riching KM, Zaman GJR, Fischer M, Klco JM, Rankovic Z. Nishiguchi G, et al. Among authors: narina s. Nat Commun. 2024 Jan 16;15(1):482. doi: 10.1038/s41467-024-44698-1. Nat Commun. 2024. PMID: 38228616 Free PMC article.
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design.
Jarusiewicz JA, Yoshimura S, Mayasundari A, Actis M, Aggarwal A, McGowan K, Yang L, Li Y, Fu X, Mishra V, Heath R, Narina S, Pruett-Miller SM, Nishiguchi G, Yang JJ, Rankovic Z. Jarusiewicz JA, et al. Among authors: narina s. ACS Med Chem Lett. 2023 Jan 4;14(2):141-145. doi: 10.1021/acsmedchemlett.2c00436. eCollection 2023 Feb 9. ACS Med Chem Lett. 2023. PMID: 36793425 Free PMC article.
Disruption of cotranscriptional splicing suggests that RBM39 is a therapeutic target in acute lymphoblastic leukemia.
Jin Q, Harris E, Myers JA, Mehmood R, Cotton A, Shirnekhi HK, Baggett DW, Wen JQ, Schild AB, Bhansali RS, Klein J, Narina S, Pieters T, Yoshimi A, Pruett-Miller SM, Kriwacki R, Abdel-Wahab O, Malinge S, Ntziachristos P, Obeng EA, Crispino JD. Jin Q, et al. Among authors: narina s. Blood. 2024 Sep 24:blood.2024024281. doi: 10.1182/blood.2024024281. Online ahead of print. Blood. 2024. PMID: 39316649 Free article.
Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators.
Barnett KR, Mobley RJ, Diedrich JD, Bergeron BP, Bhattarai KR, Monovich AC, Narina S, Yang W, Crews KR, Manring CS, Jabbour E, Paietta E, Litzow MR, Kornblau SM, Stock W, Inaba H, Jeha S, Pui CH, Mullighan CG, Relling MV, Pruett-Miller SM, Ryan RJH, Yang JJ, Evans WE, Savic D. Barnett KR, et al. Among authors: narina s. Cell Genom. 2023 Nov 20;3(12):100442. doi: 10.1016/j.xgen.2023.100442. eCollection 2023 Dec 13. Cell Genom. 2023. PMID: 38116118 Free PMC article.
Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A.
Brierley CK, Yip BH, Orlando G, Goyal H, Wen S, Wen J, Levine MF, Jakobsdottir GM, Rodriguez-Meira A, Adamo A, Bashton M, Hamblin A, Clark SA, O'Sullivan J, Murphy L, Olijnik AA, Cotton A, Narina S, Pruett-Miller SM, Enshaei A, Harrison C, Drummond M, Knapper S, Tefferi A, Antony-Debré I, Thongjuea S, Wedge DC, Constantinescu S, Papaemmanuil E, Psaila B, Crispino JD, Mead AJ. Brierley CK, et al. Among authors: narina s. bioRxiv [Preprint]. 2023 Dec 10:2023.12.08.570880. doi: 10.1101/2023.12.08.570880. bioRxiv. 2023. PMID: 38106192 Free PMC article. Preprint.
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