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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nishiguchi G, Mascibroda LG, Young SM, Caine EA, Abdelhamed S, Kooijman JJ, Miller DJ, Das S, McGowan K, Mayasundari A, Shi Z, Barajas JM, Hiltenbrand R, Aggarwal A, Chang Y, Mishra V, Narina S, Thomas M, Loughran AJ, Kalathur R, Yu K, Zhou S, Wang X, High AA, Peng J, Pruett-Miller SM, Daniels DL, Urh M, Shelat AA, Mullighan CG, Riching KM, Zaman GJR, Fischer M, Klco JM, Rankovic Z. Nishiguchi G, et al. Among authors: kalathur r. Nat Commun. 2024 Jan 16;15(1):482. doi: 10.1038/s41467-024-44698-1. Nat Commun. 2024. PMID: 38228616 Free PMC article.
Structure and selectivity in bestrophin ion channels.
Yang T, Liu Q, Kloss B, Bruni R, Kalathur RC, Guo Y, Kloppmann E, Rost B, Colecraft HM, Hendrickson WA. Yang T, et al. Among authors: kalathur rc. Science. 2014 Oct 17;346(6207):355-9. doi: 10.1126/science.1259723. Epub 2014 Sep 25. Science. 2014. PMID: 25324390 Free PMC article.
Structure-Based Design of Anticancer Prodrug PABA/NO.
Ji X, Pal A, Kalathur R, Hu X, Gu Y, Saavedra JE, Buzard GS, Srinivasan A, Keefer LK, Singh SV. Ji X, et al. Among authors: kalathur r. Drug Des Devel Ther. 2008;2:123-130. doi: 10.2147/dddt.s3931. Drug Des Devel Ther. 2008. PMID: 19662104 Free PMC article.
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB 3rd, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. Pan M, et al. Among authors: kalathur r. Nat Commun. 2021 Nov 9;12(1):6468. doi: 10.1038/s41467-021-26640-x. Nat Commun. 2021. PMID: 34753908 Free PMC article.
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk.
Baer C, Kimura S, Rana MS, Kleist AB, Flerlage T, Feith DJ, Chockley P, Walter W, Meggendorfer M, Olson TL, Cheon H, Olson KC, Ratan A, Mueller ML, Foran JM, Janke LJ, Qu C, Porter SN, Pruett-Miller SM, Kalathur RC, Haferlach C, Kern W, Paietta E, Thomas PG, Babu MM, Loughran TP Jr, Iacobucci I, Haferlach T, Mullighan CG. Baer C, et al. Nat Genet. 2022 May;54(5):637-648. doi: 10.1038/s41588-022-01059-2. Epub 2022 May 5. Nat Genet. 2022. PMID: 35513723 Free PMC article.
Midkine Attenuates Aβ Fibril Assembly and AmyloidPlaque Formation.
Peng J, Zaman M, Yang S, Huang Y, Yarbro J, Wang Z, Liu D, Soliman H, Hemphill A, Harvey S, Pruett-Miller S, Stewart V, Tanwar A, Kalathur R, Grace C, Turk M, Chittori S, Jiao Y, Wu Z, High A, Wang X, Serrano G, Beach T, Yu G, Yang Y, Chen PC. Peng J, et al. Among authors: kalathur r. Res Sq [Preprint]. 2024 Jun 7:rs.3.rs-4361125. doi: 10.21203/rs.3.rs-4361125/v1. Res Sq. 2024. PMID: 38883748 Free PMC article. Preprint.
65 results