Pasonen-Seppänen S - Search Results

1

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.

Deen AJ, Adinolfi S, Härkönen J, Patinen T, Liu X, Laitinen T, Takabe P, Kainulainen K, Pasonen-Seppänen S, Gawriyski LM, Arasu UT, Selvarajan I, Mäkinen P, Laitinen H, Kansanen E, Kaikkonen MU, Poso A, Varjosalo M, Levonen AL. Deen AJ, et al. Among authors: pasonen seppanen s. Redox Biol. 2024 Feb;69:103031. doi: 10.1016/j.redox.2024.103031. Epub 2024 Jan 4. Redox Biol. 2024. PMID: 38184997 Free PMC article.

2

Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling.

Pasonen-Seppänen S, Takabe P, Edward M, Rauhala L, Rilla K, Tammi M, Tammi R. Pasonen-Seppänen S, et al. Histochem Cell Biol. 2012 Dec;138(6):895-911. doi: 10.1007/s00418-012-1000-x. Epub 2012 Jul 24. Histochem Cell Biol. 2012. PMID: 22825838

3

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.

Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J, Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT. Aaltonen N, et al. Chem Biol. 2013 Mar 21;20(3):379-90. doi: 10.1016/j.chembiol.2013.01.012. Chem Biol. 2013. PMID: 23521796

4

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles.

Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. Rilla K, et al. Exp Cell Res. 2013 Aug 1;319(13):2006-2018. doi: 10.1016/j.yexcr.2013.05.021. Epub 2013 Jun 1. Exp Cell Res. 2013. PMID: 23732660

5

Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion.

Takabe P, Bart G, Ropponen A, Rilla K, Tammi M, Tammi R, Pasonen-Seppänen S. Takabe P, et al. Exp Cell Res. 2015 Sep 10;337(1):1-15. doi: 10.1016/j.yexcr.2015.07.026. Epub 2015 Jul 26. Exp Cell Res. 2015. PMID: 26222208

6

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression.

Deen AJ, Arasu UT, Pasonen-Seppänen S, Hassinen A, Takabe P, Wojciechowski S, Kärnä R, Rilla K, Kellokumpu S, Tammi R, Tammi M, Oikari S. Deen AJ, et al. Cell Mol Life Sci. 2016 Aug;73(16):3183-204. doi: 10.1007/s00018-016-2158-5. Epub 2016 Feb 16. Cell Mol Life Sci. 2016. PMID: 26883802 Free PMC article.

7

Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.

Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. Pantsar T, et al. Eur J Pharm Sci. 2017 Sep 30;107:97-111. doi: 10.1016/j.ejps.2017.07.002. Epub 2017 Jul 5. Eur J Pharm Sci. 2017. PMID: 28687529

8

Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C.

Hämäläinen L, Kärkkäinen E, Takabe P, Rauhala L, Bart G, Kärnä R, Pasonen-Seppänen S, Oikari S, Tammi MI, Tammi RH. Hämäläinen L, et al. Br J Dermatol. 2018 Sep;179(3):651-661. doi: 10.1111/bjd.16423. Epub 2018 May 15. Br J Dermatol. 2018. PMID: 29405260

9

Extracellular ATP activates hyaluronan synthase 2 (HAS2) in epidermal keratinocytes via P2Y₂, Ca²⁺ signaling, and MAPK pathways.

Rauhala L, Jokela T, Kärnä R, Bart G, Takabe P, Oikari S, Tammi MI, Pasonen-Seppänen S, Tammi RH. Rauhala L, et al. Biochem J. 2018 May 24;475(10):1755-1772. doi: 10.1042/BCJ20180054. Biochem J. 2018. PMID: 29626161

10

Melanocyte Hyaluronan Coat Fragmentation Enhances the UVB-Induced TLR-4 Receptor Signaling and Expression of Proinflammatory Mediators IL6, IL8, CXCL1, and CXCL10 via NF-κB Activation.

Takabe P, Kärnä R, Rauhala L, Tammi M, Tammi R, Pasonen-Seppänen S. Takabe P, et al. J Invest Dermatol. 2019 Sep;139(9):1993-2003.e4. doi: 10.1016/j.jid.2019.03.1135. Epub 2019 Mar 29. J Invest Dermatol. 2019. PMID: 30935974 Free article.

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