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Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
Deen AJ, Adinolfi S, Härkönen J, Patinen T, Liu X, Laitinen T, Takabe P, Kainulainen K, Pasonen-Seppänen S, Gawriyski LM, Arasu UT, Selvarajan I, Mäkinen P, Laitinen H, Kansanen E, Kaikkonen MU, Poso A, Varjosalo M, Levonen AL. Deen AJ, et al. Among authors: adinolfi s. Redox Biol. 2024 Feb;69:103031. doi: 10.1016/j.redox.2024.103031. Epub 2024 Jan 4. Redox Biol. 2024. PMID: 38184997 Free PMC article.
Regulation of stress signaling pathways by protein lipoxidation.
Patinen T, Adinolfi S, Cortés CC, Härkönen J, Jawahar Deen A, Levonen AL. Patinen T, et al. Among authors: adinolfi s. Redox Biol. 2019 May;23:101114. doi: 10.1016/j.redox.2019.101114. Epub 2019 Jan 16. Redox Biol. 2019. PMID: 30709792 Free PMC article. Review.
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer.
Adinolfi S, Patinen T, Jawahar Deen A, Pitkänen S, Härkönen J, Kansanen E, Küblbeck J, Levonen AL. Adinolfi S, et al. Redox Biol. 2023 Jul;63:102726. doi: 10.1016/j.redox.2023.102726. Epub 2023 Apr 29. Redox Biol. 2023. PMID: 37146513 Free PMC article. Review.
Regulation of stress signaling pathways by nitro-fatty acids.
Deen AJ, Sihvola V, Härkönen J, Patinen T, Adinolfi S, Levonen AL. Deen AJ, et al. Among authors: adinolfi s. Nitric Oxide. 2018 Mar 19:S1089-8603(17)30323-3. doi: 10.1016/j.niox.2018.03.012. Online ahead of print. Nitric Oxide. 2018. PMID: 29567143 Review.
PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer.
Talwelkar SS, Mäyränpää MI, Schüler J, Linnavirta N, Hemmes A, Adinolfi S, Kankainen M, Sommergruber W, Levonen AL, Räsänen J, Knuuttila A, Verschuren EW, Wennerberg K. Talwelkar SS, et al. Among authors: adinolfi s. Mol Oncol. 2023 May;17(5):747-764. doi: 10.1002/1878-0261.13342. Epub 2023 Jan 25. Mol Oncol. 2023. PMID: 36423211 Free PMC article.
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice.
Ruotsalainen AK, Lappalainen JP, Heiskanen E, Merentie M, Sihvola V, Näpänkangas J, Lottonen-Raikaslehto L, Kansanen E, Adinolfi S, Kaarniranta K, Ylä-Herttuala S, Jauhiainen M, Pirinen E, Levonen AL. Ruotsalainen AK, et al. Among authors: adinolfi s. Cardiovasc Res. 2019 Jan 1;115(1):243-254. doi: 10.1093/cvr/cvy143. Cardiovasc Res. 2019. PMID: 29917052
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.
Pippione AC, Kovachka S, Vigato C, Bertarini L, Mannella I, Sainas S, Rolando B, Denasio E, Piercy-Mycock H, Romalho L, Salladini E, Adinolfi S, Zonari D, Peraldo-Neia C, Chiorino G, Passoni A, Mirza OA, Frydenvang K, Pors K, Lolli ML, Spyrakis F, Oliaro-Bosso S, Boschi D. Pippione AC, et al. Among authors: adinolfi s. Eur J Med Chem. 2024 Mar 15;268:116193. doi: 10.1016/j.ejmech.2024.116193. Epub 2024 Feb 7. Eur J Med Chem. 2024. PMID: 38364714 Free article.
On the regulation of human D-aspartate oxidase.
Rabattoni V, Motta Z, Miceli M, Molla G, Fissore A, Adinolfi S, Pollegioni L, Sacchi S. Rabattoni V, et al. Among authors: adinolfi s. Protein Sci. 2023 Nov;32(11):e4802. doi: 10.1002/pro.4802. Protein Sci. 2023. PMID: 37805834 Free PMC article.
New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold.
Pippione AC, Kilic-Kurt Z, Kovachka S, Sainas S, Rolando B, Denasio E, Pors K, Adinolfi S, Zonari D, Bagnati R, Lolli ML, Spyrakis F, Oliaro-Bosso S, Boschi D. Pippione AC, et al. Among authors: adinolfi s. Eur J Med Chem. 2022 Jul 5;237:114366. doi: 10.1016/j.ejmech.2022.114366. Epub 2022 Apr 13. Eur J Med Chem. 2022. PMID: 35447434 Free article.
53 results