Thomä NH - Search Results

1

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.

Schröder M, Renatus M, Liang X, Meili F, Zoller T, Ferrand S, Gauter F, Li X, Sigoillot F, Gleim S, Stachyra TM, Thomas JR, Begue D, Khoshouei M, Lefeuvre P, Andraos-Rey R, Chung B, Ma R, Pinch B, Hofmann A, Schirle M, Schmiedeberg N, Imbach P, Gorses D, Calkins K, Bauer-Probst B, Maschlej M, Niederst M, Maher R, Henault M, Alford J, Ahrne E, Tordella L, Hollingworth G, Thomä NH, Vulpetti A, Radimerski T, Holzer P, Carbonneau S, Thoma CR. Schröder M, et al. Among authors: thoma nh. Nat Commun. 2024 Jan 4;15(1):275. doi: 10.1038/s41467-023-44237-4. Nat Commun. 2024. PMID: 38177131 Free PMC article.

2

Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II.

Thomä NH, Iakovenko A, Kalinin A, Waldmann H, Goody RS, Alexandrov K. Thomä NH, et al. Biochemistry. 2001 Jan 9;40(1):268-74. doi: 10.1021/bi002034p. Biochemistry. 2001. PMID: 11141079

3

Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins.

Kalinin A, Thomä NH, Iakovenko A, Heinemann I, Rostkova E, Constantinescu AT, Alexandrov K. Kalinin A, et al. Among authors: thoma nh. Protein Expr Purif. 2001 Jun;22(1):84-91. doi: 10.1006/prep.2001.1423. Protein Expr Purif. 2001. PMID: 11388804

4

Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment.

Blankenfeldt W, Thomä NH, Wray JS, Gautel M, Schlichting I. Blankenfeldt W, et al. Among authors: thoma nh. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17713-7. doi: 10.1073/pnas.0606741103. Epub 2006 Nov 9. Proc Natl Acad Sci U S A. 2006. PMID: 17095604 Free PMC article.

5

Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase.

Thomä NH, Meier TW, Evans PR, Leadlay PF. Thomä NH, et al. Biochemistry. 1998 Oct 13;37(41):14386-93. doi: 10.1021/bi981375o. Biochemistry. 1998. PMID: 9772164

6

Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

Thomä NH, Iakovenko A, Goody RS, Alexandrov K. Thomä NH, et al. J Biol Chem. 2001 Dec 28;276(52):48637-43. doi: 10.1074/jbc.M108241200. Epub 2001 Oct 23. J Biol Chem. 2001. PMID: 11675392 Free article.

7

Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates.

Dursina B, Thomä NH, Sidorovitch V, Niculae A, Iakovenko A, Rak A, Albert S, Ceacareanu AC, Kölling R, Herrmann C, Goody RS, Alexandrov K. Dursina B, et al. Among authors: thoma nh. Biochemistry. 2002 May 28;41(21):6805-16. doi: 10.1021/bi016067w. Biochemistry. 2002. PMID: 12022885

8

Homology modeling of human methylmalonyl-CoA mutase: a structural basis for point mutations causing methylmalonic aciduria.

Thomä NH, Leadlay PF. Thomä NH, et al. Protein Sci. 1996 Sep;5(9):1922-7. doi: 10.1002/pro.5560050919. Protein Sci. 1996. PMID: 8880917 Free PMC article.

9

Determinants and dynamics of genome accessibility.

Bell O, Tiwari VK, Thomä NH, Schübeler D. Bell O, et al. Among authors: thoma nh. Nat Rev Genet. 2011 Jul 12;12(8):554-64. doi: 10.1038/nrg3017. Nat Rev Genet. 2011. PMID: 21747402 Review.

10

Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate.

Thomä NH, Niculae A, Goody RS, Alexandrov K. Thomä NH, et al. J Biol Chem. 2001 Dec 28;276(52):48631-6. doi: 10.1074/jbc.M106470200. Epub 2001 Oct 8. J Biol Chem. 2001. PMID: 11591706 Free article.

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