Williams DC - Search Results

1

Synthesis and Pro-Apoptotic Effects of Nitrovinylanthracenes and Related Compounds in Chronic Lymphocytic Leukaemia (CLL) and Burkitt's Lymphoma (BL).

Byrne AJ, Bright SA, McKeown JP, Bergin A, Twamley B, McElligott AM, Noorani S, Kandwal S, Fayne D, O'Boyle NM, Williams DC, Meegan MJ. Byrne AJ, et al. Among authors: williams dc. Molecules. 2023 Dec 14;28(24):8095. doi: 10.3390/molecules28248095. Molecules. 2023. PMID: 38138584 Free PMC article.

2

Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells.

Meegan MJ, Hughes RB, Lloyd DG, Williams DC, Zisterer DM. Meegan MJ, et al. Among authors: williams dc. J Med Chem. 2001 Mar 29;44(7):1072-84. doi: 10.1021/jm001119l. J Med Chem. 2001. PMID: 11297454

3

Ethyl side-chain modifications in novel flexible antiestrogens--design, synthesis and biological efficacy in assay against the MCF-7 breast tumor cell line.

Meegan MJ, Hughes RB, Lloyd DG, Williams DC, Zisterer DM. Meegan MJ, et al. Among authors: williams dc. Anticancer Drug Des. 2001 Feb;16(1):57-69. Anticancer Drug Des. 2001. PMID: 11762645

4

Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor.

Lloyd DG, Hughes RB, Zisterer DM, Williams DC, Fattorusso C, Catalanotti B, Campiani G, Meegan MJ. Lloyd DG, et al. Among authors: williams dc. J Med Chem. 2004 Nov 4;47(23):5612-5. doi: 10.1021/jm0495834. J Med Chem. 2004. PMID: 15509159

5

Target specific virtual screening: optimization of an estrogen receptor screening platform.

Knox AJ, Meegan MJ, Sobolev V, Frost D, Zisterer DM, Williams DC, Lloyd DG. Knox AJ, et al. Among authors: williams dc. J Med Chem. 2007 Nov 1;50(22):5301-10. doi: 10.1021/jm0700262. Epub 2007 Oct 5. J Med Chem. 2007. PMID: 17918820

6

A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.

Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y. Verma NK, et al. Among authors: williams dc. J Mol Med (Berl). 2008 Apr;86(4):457-69. doi: 10.1007/s00109-008-0312-8. Epub 2008 Feb 13. J Mol Med (Berl). 2008. PMID: 18270678

7

The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.

Bright SA, Greene LM, Greene TF, Campiani G, Butini S, Brindisi M, Lawler M, Meegan MJ, Williams DC, Zisterer DM. Bright SA, et al. Among authors: williams dc. Biochem Pharmacol. 2009 Feb 1;77(3):310-21. doi: 10.1016/j.bcp.2008.10.008. Epub 2008 Oct 30. Biochem Pharmacol. 2009. PMID: 19014913

8

Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.

Knox AJ, Price T, Pawlak M, Golfis G, Flood CT, Fayne D, Williams DC, Meegan MJ, Lloyd DG. Knox AJ, et al. Among authors: williams dc. J Med Chem. 2009 Apr 23;52(8):2177-80. doi: 10.1021/jm801569z. J Med Chem. 2009. PMID: 19331414

9

Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.

Nathwani SM, Butler S, Meegan MJ, Campiani G, Lawler M, Williams DC, Zisterer DM. Nathwani SM, et al. Among authors: williams dc. Cancer Chemother Pharmacol. 2010 Jan;65(2):289-300. doi: 10.1007/s00280-009-1033-6. Cancer Chemother Pharmacol. 2010. PMID: 19479253

10

Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.

Cloonan SM, Keating JJ, Butler SG, Knox AJ, Jørgensen AM, Peters GH, Rai D, Corrigan D, Lloyd DG, Williams DC, Meegan MJ. Cloonan SM, et al. Among authors: williams dc. Eur J Med Chem. 2009 Dec;44(12):4862-88. doi: 10.1016/j.ejmech.2009.07.027. Epub 2009 Aug 6. Eur J Med Chem. 2009. PMID: 19717215

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