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Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Casebeer SW, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: shelton pmm. J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. Epub 2023 Dec 22. J Am Chem Soc. 2024. PMID: 38134034
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Warrington S, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: shelton pmm. bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.559391. doi: 10.1101/2023.09.25.559391. bioRxiv. 2023. Update in: J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. PMID: 37808863 Free PMC article. Updated. Preprint.
A wrench in the motor.
Shelton PMM, Kapoor TM. Shelton PMM, et al. Nat Chem Biol. 2022 Apr;18(4):355-356. doi: 10.1038/s41589-021-00897-1. Nat Chem Biol. 2022. PMID: 34857957 No abstract available.
Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase.
Mickolajczyk KJ, Shelton PMM, Grasso M, Cao X, Warrington SE, Aher A, Liu S, Kapoor TM. Mickolajczyk KJ, et al. Among authors: shelton pmm. Biophys J. 2021 Mar 16;120(6):1020-1030. doi: 10.1016/j.bpj.2020.11.2276. Epub 2020 Dec 17. Biophys J. 2021. PMID: 33340543 Free PMC article.
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex.
Chen J, Malone B, Llewellyn E, Grasso M, Shelton PMM, Olinares PDB, Maruthi K, Eng E, Vatandaslar H, Chait BT, Kapoor T, Darst SA, Campbell EA. Chen J, et al. Among authors: shelton pmm. bioRxiv [Preprint]. 2020 Jul 13:2020.07.08.194084. doi: 10.1101/2020.07.08.194084. bioRxiv. 2020. Update in: Cell. 2020 Sep 17;182(6):1560-1573.e13. doi: 10.1016/j.cell.2020.07.033. PMID: 32676607 Free PMC article. Updated. Preprint.
11 results