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Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Casebeer SW, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: huggins dj. J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. Epub 2023 Dec 22. J Am Chem Soc. 2024. PMID: 38134034
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Balbach M, Rossetti T, Ferreira J, Ghanem L, Ritagliati C, Myers RW, Huggins DJ, Steegborn C, Miranda IC, Meinke PT, Buck J, Levin LR. Balbach M, et al. Among authors: huggins dj. Nat Commun. 2023 Feb 14;14(1):637. doi: 10.1038/s41467-023-36119-6. Nat Commun. 2023. PMID: 36788210 Free PMC article.
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Warrington S, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM. Ramsey JR, et al. Among authors: huggins dj. bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.559391. doi: 10.1101/2023.09.25.559391. bioRxiv. 2023. Update in: J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. PMID: 37808863 Free PMC article. Updated. Preprint.
Indazole to 2-Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity.
Sun S, Ginn J, Kochanczyk T, Arango N, Jiang X, Huggins DJ, Bean J, Michino M, Baxt L, Liverton N, Meinke PT, Bryk R. Sun S, et al. Among authors: huggins dj. Angew Chem Int Ed Engl. 2024 Oct 24;63(44):e202407276. doi: 10.1002/anie.202407276. Epub 2024 Sep 20. Angew Chem Int Ed Engl. 2024. PMID: 38997232
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055.
Michino M, Khan TA, Miller MW, Fukase Y, Vendome J, Adura C, Glickman JF, Liu Y, Wan L, Allis CD, Stamford AW, Meinke PT, Renzetti LM, Kargman S, Liverton NJ, Huggins DJ. Michino M, et al. Among authors: huggins dj. ACS Med Chem Lett. 2024 Mar 12;15(4):524-532. doi: 10.1021/acsmedchemlett.4c00016. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628784
Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior.
Zeledon EV, Baxt LA, Khan TA, Michino M, Miller M, Huggins DJ, Jiang CS, Vosshall LB, Duvall LB. Zeledon EV, et al. Among authors: huggins dj. bioRxiv [Preprint]. 2024 Mar 5:2024.02.28.582529. doi: 10.1101/2024.02.28.582529. bioRxiv. 2024. Update in: Parasit Vectors. 2024 Jun 28;17(1):276. doi: 10.1186/s13071-024-06347-w. PMID: 38464241 Free PMC article. Updated. Preprint.
63 results