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Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.
Amrhein JA, Berger LM, Balourdas DI, Joerger AC, Menge A, Krämer A, Frischkorn JM, Berger BT, Elson L, Kaiser A, Schubert-Zsilavecz M, Müller S, Knapp S, Hanke T. Amrhein JA, et al. Among authors: menge a. J Med Chem. 2024 Jan 11;67(1):674-690. doi: 10.1021/acs.jmedchem.3c01980. Epub 2023 Dec 21. J Med Chem. 2024. PMID: 38126712
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Balzulat A, Zhu WF, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, Dubiel M, Frank A, Menge A, Hebchen M, Metzner K, Lu R, Lukowski R, Ruth P, Knapp S, Müller S, Steinhilber D, Hänelt I, Stark H, Proschak E, Schmidtko A. Balzulat A, et al. Among authors: menge a. Adv Sci (Weinh). 2024 Apr;11(15):e2307237. doi: 10.1002/advs.202307237. Epub 2024 Feb 13. Adv Sci (Weinh). 2024. PMID: 38350720 Free PMC article.
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.
Rak M, Menge A, Tesch R, Berger LM, Balourdas DI, Shevchenko E, Krämer A, Elson L, Berger BT, Abdi I, Wahl LM, Poso A, Kaiser A, Hanke T, Kronenberger T, Joerger AC, Müller S, Knapp S. Rak M, et al. Among authors: menge a. J Med Chem. 2024 Mar 14;67(5):3813-3842. doi: 10.1021/acs.jmedchem.3c02217. Epub 2024 Feb 29. J Med Chem. 2024. PMID: 38422480
Chemogenomics for NR1 nuclear hormone receptors.
Isigkeit L, Schallmayer E, Busch R, Brunello L, Menge A, Elson L, Müller S, Knapp S, Stolz A, Marschner JA, Merk D. Isigkeit L, et al. Among authors: menge a. Nat Commun. 2024 Jun 18;15(1):5201. doi: 10.1038/s41467-024-49493-6. Nat Commun. 2024. PMID: 38890295 Free PMC article.
A data science roadmap for open science organizations engaged in early-stage drug discovery.
Edfeldt K, Edwards AM, Engkvist O, Günther J, Hartley M, Hulcoop DG, Leach AR, Marsden BD, Menge A, Misquitta L, Müller S, Owen DR, Schütt KT, Skelton N, Steffen A, Tropsha A, Vernet E, Wang Y, Wellnitz J, Willson TM, Clevert DA, Haibe-Kains B, Schiavone LH, Schapira M. Edfeldt K, et al. Among authors: menge a. Nat Commun. 2024 Jul 5;15(1):5640. doi: 10.1038/s41467-024-49777-x. Nat Commun. 2024. PMID: 38965235 Free PMC article. Review.
8th vaccine renaissance: A creative nexus for vaccine developers.
Johnson H, Moise L, Menge A, Beseme S, De Groot AS. Johnson H, et al. Among authors: menge a. Hum Vaccin Immunother. 2015;11(9):2294-5. doi: 10.1080/21645515.2015.1069453. Epub 2015 Jul 9. Hum Vaccin Immunother. 2015. PMID: 26158225 Free PMC article. No abstract available.
Histology of plastic embedded amphibian embryos and larvae.
Kurth T, Weiche S, Vorkel D, Kretschmar S, Menge A. Kurth T, et al. Among authors: menge a. Genesis. 2012 Mar;50(3):235-50. doi: 10.1002/dvg.20821. Epub 2011 Dec 27. Genesis. 2012. PMID: 22083609 Review.
89 results