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Page 1
Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes.
Isobe T, Kucinski I, Barile M, Wang X, Hannah R, Bastos HP, Chabra S, Vijayabaskar MS, Sturgess KHM, Williams MJ, Giotopoulos G, Marando L, Li J, Rak J, Gozdecka M, Prins D, Shepherd MS, Watcham S, Green AR, Kent DG, Vassiliou GS, Huntly BJP, Wilson NK, Göttgens B. Isobe T, et al. Among authors: giotopoulos g. Cell Genom. 2023 Oct 27;3(12):100426. doi: 10.1016/j.xgen.2023.100426. eCollection 2023 Dec 13. Cell Genom. 2023. PMID: 38116120 Free PMC article.
In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis.
Lara-Astiaso D, Goñi-Salaverri A, Mendieta-Esteban J, Narayan N, Del Valle C, Gross T, Giotopoulos G, Beinortas T, Navarro-Alonso M, Aguado-Alvaro LP, Zazpe J, Marchese F, Torrea N, Calvo IA, Lopez CK, Alignani D, Lopez A, Saez B, Taylor-King JP, Prosper F, Fortelny N, Huntly BJP. Lara-Astiaso D, et al. Among authors: giotopoulos g. Nat Genet. 2023 Sep;55(9):1542-1554. doi: 10.1038/s41588-023-01471-2. Epub 2023 Aug 14. Nat Genet. 2023. PMID: 37580596 Free PMC article.
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.
Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS, Asby R, van de Lagemaat LN, Mapperley C, James SC, Prehn JHM, Tzelepis K, Rouault-Pierre K, Vassiliou GS, Kranc KR, Helgason GV, Huntly BJP, Gallipoli P. Woodley K, et al. Among authors: giotopoulos g. Nat Commun. 2023 Apr 14;14(1):2132. doi: 10.1038/s41467-023-37652-0. Nat Commun. 2023. PMID: 37059720 Free PMC article.
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia.
Agrawal-Singh S, Bagri J, Giotopoulos G, Azazi DMA, Horton SJ, Lopez CK, Anand S, Bach AS, Stedham F, Antrobus R, Houghton JW, Vassiliou GS, Sasca D, Yun H, Whetton AD, Huntly BJP. Agrawal-Singh S, et al. Among authors: giotopoulos g. Blood. 2023 Apr 6;141(14):1737-1754. doi: 10.1182/blood.2022016528. Blood. 2023. PMID: 36577137 Free PMC article.
Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis.
Gupta S, Dovey OM, Domingues AF, Cyran OW, Cash CM, Giotopoulos G, Rak J, Cooper J, Gozdecka M, Dijkhuis L, Asby RJ, Al-Jabery N, Hernandez-Hernandez V, Prabakaran S, Huntly BJ, Vassiliou GS, Pina C. Gupta S, et al. Among authors: giotopoulos g. Sci Adv. 2022 Aug 5;8(31):eabn4886. doi: 10.1126/sciadv.abn4886. Epub 2022 Aug 3. Sci Adv. 2022. PMID: 35921412 Free PMC article.
Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma.
Anderson GSF, Ballester-Beltran J, Giotopoulos G, Guerrero JA, Surget S, Williamson JC, So T, Bloxham D, Aubareda A, Asby R, Walker I, Jenkinson L, Soilleux EJ, Roy JP, Teodósio A, Ficken C, Officer-Jones L, Nasser S, Skerget S, Keats JJ, Greaves P, Tai YT, Anderson KC, MacFarlane M, Thaventhiran JE, Huntly BJP, Lehner PJ, Chapman MA. Anderson GSF, et al. Among authors: giotopoulos g. Blood. 2022 Apr 21;139(16):2471-2482. doi: 10.1182/blood.2021015161. Blood. 2022. PMID: 35134130 Free PMC article.
KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia.
Arede L, Foerner E, Wind S, Kulkarni R, Domingues AF, Giotopoulos G, Kleinwaechter S, Mollenhauer-Starkl M, Davison H, Chandru A, Asby R, Samarista R, Gupta S, Forte D, Curti A, Scheer E, Huntly BJP, Tora L, Pina C. Arede L, et al. Among authors: giotopoulos g. Blood Adv. 2022 Jan 11;6(1):165-180. doi: 10.1182/bloodadvances.2020002842. Blood Adv. 2022. PMID: 34654054 Free PMC article.
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Yun H, Narayan N, Vohra S, Giotopoulos G, Mupo A, Madrigal P, Sasca D, Lara-Astiaso D, Horton SJ, Agrawal-Singh S, Meduri E, Basheer F, Marando L, Gozdecka M, Dovey OM, Castillo-Venzor A, Wang X, Gallipoli P, Müller-Tidow C, Osborne CS, Vassiliou GS, Huntly BJP. Yun H, et al. Among authors: giotopoulos g. Nat Genet. 2021 Oct;53(10):1443-1455. doi: 10.1038/s41588-021-00925-9. Epub 2021 Sep 23. Nat Genet. 2021. PMID: 34556857 Free PMC article.
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Gong C, Krupka JA, Gao J, Grigoropoulos NF, Giotopoulos G, Asby R, Screen M, Usheva Z, Cucco F, Barrans S, Painter D, Zaini NBM, Haupl B, Bornelöv S, Ruiz De Los Mozos I, Meng W, Zhou P, Blain AE, Forde S, Matthews J, Khim Tan MG, Burke GAA, Sze SK, Beer P, Burton C, Campbell P, Rand V, Turner SD, Ule J, Roman E, Tooze R, Oellerich T, Huntly BJ, Turner M, Du MQ, Samarajiwa SA, Hodson DJ. Gong C, et al. Among authors: giotopoulos g. Mol Cell. 2021 Oct 7;81(19):4059-4075.e11. doi: 10.1016/j.molcel.2021.07.041. Epub 2021 Aug 25. Mol Cell. 2021. PMID: 34437837 Free article.
CML: new tools to answer old questions.
Giotopoulos G, Huntly BJP. Giotopoulos G, et al. Blood. 2020 Jun 25;135(26):2327-2328. doi: 10.1182/blood.2020005599. Blood. 2020. PMID: 32585023 Free article. No abstract available.
34 results