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Page 1
Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes.
Isobe T, Kucinski I, Barile M, Wang X, Hannah R, Bastos HP, Chabra S, Vijayabaskar MS, Sturgess KHM, Williams MJ, Giotopoulos G, Marando L, Li J, Rak J, Gozdecka M, Prins D, Shepherd MS, Watcham S, Green AR, Kent DG, Vassiliou GS, Huntly BJP, Wilson NK, Göttgens B. Isobe T, et al. Among authors: bastos hp. Cell Genom. 2023 Oct 27;3(12):100426. doi: 10.1016/j.xgen.2023.100426. eCollection 2023 Dec 13. Cell Genom. 2023. PMID: 38116120 Free PMC article.
Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures.
Oedekoven CA, Belmonte M, Bode D, Hamey FK, Shepherd MS, Che JLC, Boyd G, McDonald C, Belluschi S, Diamanti E, Bastos HP, Bridge KS, Göttgens B, Laurenti E, Kent DG. Oedekoven CA, et al. Among authors: bastos hp. Stem Cell Reports. 2021 Jun 8;16(6):1614-1628. doi: 10.1016/j.stemcr.2021.04.002. Epub 2021 May 6. Stem Cell Reports. 2021. PMID: 33961793 Free PMC article.
Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans.
Mende N, Bastos HP, Santoro A, Mahbubani KT, Ciaurro V, Calderbank EF, Quiroga Londoño M, Sham K, Mantica G, Morishima T, Mitchell E, Lidonnici MR, Meier-Abt F, Hayler D, Jardine L, Curd A, Haniffa M, Ferrari G, Takizawa H, Wilson NK, Göttgens B, Saeb-Parsy K, Frontini M, Laurenti E. Mende N, et al. Among authors: bastos hp. Blood. 2022 Jun 9;139(23):3387-3401. doi: 10.1182/blood.2021013450. Blood. 2022. PMID: 35073399 Free PMC article.
STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion.
Li J, Williams MJ, Park HJ, Bastos HP, Wang X, Prins D, Wilson NK, Johnson C, Sham K, Wantoch M, Watcham S, Kinston SJ, Pask DC, Hamilton TL, Sneade R, Waller AK, Ghevaert C, Vassiliou GS, Laurenti E, Kent DG, Göttgens B, Green AR. Li J, et al. Among authors: bastos hp. Blood. 2022 Oct 6;140(14):1592-1606. doi: 10.1182/blood.2021014009. Blood. 2022. PMID: 35767701 Free PMC article.
Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition.
Williams MJ, Wang X, Bastos HP, Grondys-Kotarba G, Wu Q, Jin S, Johnson CS, Mende N, Calderbank EF, Wantoch M, Park HJ, Mantica G, Hannah RL, Wilson NK, Pask DC, Hamilton TL, Kinston SJ, Asby R, Sneade R, Baxter EJ, Campbell PJ, Vassiliou GS, Laurenti E PhD, Li J, Gottgens B, Green AR. Williams MJ, et al. Among authors: bastos hp. Blood Adv. 2024 Oct 7:bloodadvances.2024014046. doi: 10.1182/bloodadvances.2024014046. Online ahead of print. Blood Adv. 2024. PMID: 39374575
Functional coherence metrics in protein families.
Bastos HP, Sousa L, Clarke LA, Couto FM. Bastos HP, et al. J Biomed Semantics. 2016 Jun 23;7(1):41. doi: 10.1186/s13326-016-0076-y. J Biomed Semantics. 2016. PMID: 27338101 Free PMC article.
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