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Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Chrustowicz J, Sherpa D, Li J, Langlois CR, Papadopoulou EC, Vu DT, Hehl LA, Karayel Ö, Beier V, von Gronau S, Müller J, Prabu JR, Mann M, Kleiger G, Alpi AF, Schulman BA. Chrustowicz J, et al. Among authors: li j. Mol Cell. 2024 Jan 18;84(2):293-308.e14. doi: 10.1016/j.molcel.2023.11.027. Epub 2023 Dec 18. Mol Cell. 2024. PMID: 38113892 Free article.
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Scott DC, King MT, Baek K, Gee CT, Kalathur R, Li J, Purser N, Nourse A, Chai SC, Vaithiyalingam S, Chen T, Lee RE, Elledge SJ, Kleiger G, Schulman BA. Scott DC, et al. Among authors: li j. Mol Cell. 2023 Mar 2;83(5):770-786.e9. doi: 10.1016/j.molcel.2023.01.019. Epub 2023 Feb 16. Mol Cell. 2023. PMID: 36805027 Free PMC article.
Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G. Li J, et al. Mol Cell. 2024 Apr 4;84(7):1304-1320.e16. doi: 10.1016/j.molcel.2024.01.022. Epub 2024 Feb 20. Mol Cell. 2024. PMID: 38382526 Free PMC article.
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