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The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo.
Vind AC, Wu Z, Firdaus MJ, Snieckute G, Toh GA, Jessen M, Martínez JF, Haahr P, Andersen TL, Blasius M, Koh LF, Maartensson NL, Common JEA, Gyrd-Hansen M, Zhong FL, Bekker-Jensen S. Vind AC, et al. Among authors: blasius m. Mol Cell. 2024 Nov 19:S1097-2765(24)00884-0. doi: 10.1016/j.molcel.2024.10.044. Online ahead of print. Mol Cell. 2024. PMID: 39591967
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging.
Snieckute G, Ryder L, Vind AC, Wu Z, Arendrup FS, Stoneley M, Chamois S, Martinez-Val A, Leleu M, Dreos R, Russell A, Gay DM, Genzor AV, Choi BS, Basse AL, Sass F, Dall M, Dollet LCM, Blasius M, Willis AE, Lund AH, Treebak JT, Olsen JV, Poulsen SS, Pownall ME, Jensen BAH, Clemmensen C, Gerhart-Hines Z, Gatfield D, Bekker-Jensen S. Snieckute G, et al. Among authors: blasius m. Science. 2023 Dec 8;382(6675):eadf3208. doi: 10.1126/science.adf3208. Epub 2023 Dec 8. Science. 2023. PMID: 38060659
Run, Ribosome, Run: From Compromised Translation to Human Health.
Vind AC, Snieckute G, Bekker-Jensen S, Blasius M. Vind AC, et al. Among authors: blasius m. Antioxid Redox Signal. 2023 Aug;39(4-6):336-350. doi: 10.1089/ars.2022.0157. Epub 2023 May 17. Antioxid Redox Signal. 2023. PMID: 36825529 Review.
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response.
Snieckute G, Genzor AV, Vind AC, Ryder L, Stoneley M, Chamois S, Dreos R, Nordgaard C, Sass F, Blasius M, López AR, Brynjólfsdóttir SH, Andersen KL, Willis AE, Frankel LB, Poulsen SS, Gatfield D, Gerhart-Hines Z, Clemmensen C, Bekker-Jensen S. Snieckute G, et al. Among authors: blasius m. Cell Metab. 2022 Dec 6;34(12):2036-2046.e8. doi: 10.1016/j.cmet.2022.10.011. Epub 2022 Nov 15. Cell Metab. 2022. PMID: 36384144 Free PMC article.
ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle.
Nordgaard C, Vind AC, Stonadge A, Kjøbsted R, Snieckute G, Antas P, Blasius M, Reinert MS, Del Val AM, Bekker-Jensen DB, Haahr P, Miroshnikova YA, Mazouzi A, Falk S, Perrier-Groult E, Tiedje C, Li X, Jakobsen JR, Jørgensen NO, Wojtaszewski JF, Mallein-Gerin F, Andersen JL, Pennisi CP, Clemmensen C, Kassem M, Jafari A, Brummelkamp T, Li VS, Wickström SA, Olsen JV, Blanco G, Bekker-Jensen S. Nordgaard C, et al. Among authors: blasius m. EMBO J. 2022 Sep 1;41(17):e111650. doi: 10.15252/embj.2022111650. Epub 2022 Jul 28. EMBO J. 2022. PMID: 35899396 Free PMC article.
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains.
Vind AC, Snieckute G, Blasius M, Tiedje C, Krogh N, Bekker-Jensen DB, Andersen KL, Nordgaard C, Tollenaere MAX, Lund AH, Olsen JV, Nielsen H, Bekker-Jensen S. Vind AC, et al. Among authors: blasius m. Mol Cell. 2020 May 21;78(4):700-713.e7. doi: 10.1016/j.molcel.2020.03.021. Epub 2020 Apr 13. Mol Cell. 2020. PMID: 32289254 Free article.
31 results